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Titolo:
Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells
Autore:
Banno, Y; Wang, S; Ito, Y; Izumi, T; Nakashima, S; Shimizu, T; Nozawa, Y;
Indirizzi:
Gifu Univ, Sch Med, Dept Biochem, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 Sch Med, Dept Biochem, Gifu 5008705, Japan Int Med Ctr Japan, Dept Metab Disorder, Res Inst, Tokyo 1628655, Japan IntMed Ctr Japan Tokyo Japan 1628655 er, Res Inst, Tokyo 1628655, Japan Gunma Univ, Fac Med, Dept Biochem, Gunma 3718511, Japan Gunma Univ GunmaJapan 3718511 c Med, Dept Biochem, Gunma 3718511, Japan Univ Tokyo, Fac Med, Dept Biochem & Mol Biol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Biochem & Mol Biol, Tokyo 1130033, Japan Gifu Int Inst Biotechnol, Gifu 5050116, Japan Gifu Int Inst Biotechnol Gifu Japan 5050116 technol, Gifu 5050116, Japan Inst Appl Biochem, Gifu 5050116, Japan Inst Appl Biochem Gifu Japan 5050116 t Appl Biochem, Gifu 5050116, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2271 - 2275
SICI:
0959-4965(20010720)12:10<2271:IOEAPM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIH 3T3 FIBROBLASTS; SMOOTH-MUSCLE CELLS; PROTEIN-KINASE; HYDROGEN-PEROXIDE; TYROSINE PHOSPHORYLATION; DEPENDENT MECHANISM; INDUCED APOPTOSIS; HL-60 CELLS; H2O2; BRADYKININ;
Keywords:
ERK; hydrogen peroxide; p38 MAP kinase; PC12 cells; phospholipase D;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Banno, Y Gifu Univ, Sch Med, Dept Biochem, Tsukasamachi 40, Gifu 5008705, Japan Gifu Univ Tsukasamachi 40 Gifu Japan 5008705 Gifu 5008705, Japan
Citazione:
Y. Banno et al., "Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells", NEUROREPORT, 12(10), 2001, pp. 2271-2275

Abstract

Exposure to hydrogen peroxide induced considerable activation of phospholipase D (PLD) in rat pheochromocytoma PC12 cells. This PLD activation was potentiated by orthovanadate and okadaic acid, suggesting that tyrosine kinase and serine/threonine kinase are involved. Furthermore, H2O2-induced PLD activation was partially inhibited by either MEKI inhibitor (PD98059) or p38MAP kinase inhibitor (SB203580), but a combination of both inhibitors resulted in nearly 80% suppression. The major isozyme was found to be PLD2 in PC12 cells by Western blotting analysis. When the PLD2-transfected COS-7 cells were exposed to H2O2, the PLD activation was markedly inhibited by the combined pretreatment with PD98059 and SB203580. To our knowledge, this study is the first demonstration that both ERK1/2 and p38 MAP kinase are involved in the PLD2 activation in PC12 cells exposed to H2O2. NeuroReport 12:2271-2275 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 01/12/20 alle ore 01:03:15