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Titolo:
Markedly reduced chronic nociceptive response in mice lacking the PAC(I) receptor
Autore:
Jongsma, H; Pettersson, LME; Zhang, YZ; Reimer, MK; Kanje, M; Waldenstrom, A; Sundler, F; Danielsen, N;
Indirizzi:
Univ Lund, BMC F10, Dept Physiol Sci, SE-22184 Lund, Sweden Univ Lund Lund Sweden SE-22184 , Dept Physiol Sci, SE-22184 Lund, Sweden Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Neurobiol, Boston, MA 02115 USA Dana Farber Canc Inst, Dept Paediat Oncol, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115 iat Oncol, Boston, MA 02115 USA Univ Lund, Dept Anim Physiol, SE-22362 Lund, Sweden Univ Lund Lund Sweden SE-22362 Dept Anim Physiol, SE-22362 Lund, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2215 - 2219
SICI:
0959-4965(20010720)12:10<2215:MRCNRI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; PROTEIN-KINASE-C; FORMALIN TEST; SENSORY NEURONS; NERVE INJURY; SUBSTANCE-P; SPINAL-CORD; RAT; PACAP; EXPRESSION;
Keywords:
dorsal root ganglion; formalin test; inflammation; mechanical von Frey; neuropeptides; PACAP; pain measurements; sciatic nerve injury; sensory thresholds; thermal laser;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Jongsma, H Univ Lund, BMC F10, Dept Physiol Sci, SE-22184 Lund, Sweden Univ Lund Lund Sweden SE-22184 iol Sci, SE-22184 Lund, Sweden
Citazione:
H. Jongsma et al., "Markedly reduced chronic nociceptive response in mice lacking the PAC(I) receptor", NEUROREPORT, 12(10), 2001, pp. 2215-2219

Abstract

The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Prey stimulation to investigate possible alteration of PAC(1)(-/-) mice nociceptive behaviour. Our finding, that PAC(1)(-/-) mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that thespecific PACAP-recepror PAC(1) is involved in the mediation of nociceptiveresponses during chronic conditions such as inflammation. PAC(1)(-/-) micehad small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC(1) in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC(1)(-/-) mice, implying neuroregulatory functions of PAC(1). NeuroReport 12:2215-2219 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:50:48