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Titolo:
NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model
Autore:
Sakaue, G; Shimaoka, M; Fukuoka, T; Hiroi, T; Inoue, T; Hashimoto, N; Sakaguchi, T; Sawa, Y; Morishita, R; Kiyono, H; Noguchi, K; Mashimo, T;
Indirizzi:
Osaka Univ, Sch Med, Dept Anesthesiol, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 d, Dept Anesthesiol, Osaka 5650871, Japan Osaka Univ, Sch Med, Dept Surg 1, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 ch Med, Dept Surg 1, Osaka 5650871, Japan Osaka Univ, Sch Med, Dept Geriatr, Osaka 5650871, Japan Osaka Univ OsakaJapan 5650871 h Med, Dept Geriatr, Osaka 5650871, Japan Osaka Univ, Dept Mucosal Immunol, Res Inst Microbial Dis, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 Inst Microbial Dis, Osaka 5650871, Japan Hyogo Coll Med, Dept Anat & Neurosci, Hyogo 6638501, Japan Hyogo Coll MedHyogo Japan 6638501 Anat & Neurosci, Hyogo 6638501, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2079 - 2084
SICI:
0959-4965(20010720)12:10<2079:NBDSCE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SPINAL NERVE LIGATION; NECROSIS-FACTOR-ALPHA; TRANSCRIPTION FACTOR; GENE-THERAPY; CELLS; NEURONS; ACTIVATION; INHIBITION; ASTROCYTES;
Keywords:
cytokine; gene therapy; hyperalgesia; nerve injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Sakaue, G Osaka Univ, Sch Med, Dept Anesthesiol, 2-2 Yamada Oka, Osaka 5650871, Japan Osaka Univ 2-2 Yamada Oka Osaka Japan 5650871 ka 5650871, Japan
Citazione:
G. Sakaue et al., "NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model", NEUROREPORT, 12(10), 2001, pp. 2079-2084

Abstract

Pro-inflammatory cytokines have been shown to be involved in the genesis, persistence. and severity of neuropathic pain following nerve injury. The transcription factor, nuclear factor-kappa B (NF-kappaB), plays a pivotal role in regulating proinflammatory cytokine gene expression. To elucidate therole of NF-kappaB in the pathogenesis of neuropathic pain, using a gene-based approach of NF-kappaB decoy, we tested whether the activated NF-kappaB affected pain behavior via the expression of inflammatory mediators. Singleendoneurial injections of NF-kappaB decoy. at the site of nerve lesion, significantly alleviated thermal hyperalgesia for up to 2 weeks and suppressed the expression of mRNA of the inflammatory cytokines, iNOS, and adhesion molecules at the site of nerve injury. This finding suggests that a perineural inflammatory cascade, that involves NF-kappaB, is involved in the pathogenesis of neuropathic pain. NeuroReport 12:2079-2084 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:20:48