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Titolo:
Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro
Autore:
Gates, M; Ogden, A; Bleakman, D;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Div Neurosci, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 osci, Indianapolis, IN 46285 USA
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 8, volume: 40, anno: 2001,
pagine: 984 - 991
SICI:
0028-3908(200106)40:8<984:PEOARP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUR6 KAINATE RECEPTOR; HIPPOCAMPAL-NEURONS; GLUTAMATE RECEPTORS; PURKINJE-CELLS; ACID; CYCLOTHIAZIDE; ANIRACETAM; DESENSITIZATION; MODULATION; CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bleakman, D Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Div Neurosci, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 apolis, IN 46285 USA
Citazione:
M. Gates et al., "Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro", NEUROPHARM, 40(8), 2001, pp. 984-991

Abstract

The present study describes the pharmacological activity of two novel positive allosteric modulators at AMPA receptors in acutely isolated rat cerebellar Purkinje neurons and cultured rat hippocampal neurons. Currents elicited by application of glutamate (100 muM) to isolated cerebellar Purkinje neurons were potentiated by LY392098, LY404187, cyclothiazide, CX516 and aniracetam. The rank order of potency was LY404187 > LY392098 > cyclothiazide >CX516 > aniracetam. LY392098 displayed a higher maximal efficacy than the other compounds examined. AMPA-activated inward currents in cultured rat hippocampal neurons were potentiated by LY392098, LY404187 and cyclothiazide in a reversible and concentration-dependent manner although considerable heterogeneity in the magnitude of response from cell to cell was observed. LY392098 was ineffective in potentiating AMPA receptor responses when dialyzed via the intracellular solution. The selectivity profiles of the two novelAMPA receptor potentiators were examined. LY392098 or LY404187 had minimalactivity on NMDA receptor responses, on voltage-gated calcium channel currents in cultured hippocampal neurons and on GluR5 kainate receptor currentsin acutely isolated rat dorsal root ganglion neurons. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:02:47