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Titolo:
Reduced L-dopa absorption and increased clinical fluctuations in Helicobacter pylori-infected Parkinson's disease patients
Autore:
Pierantozzi, M; Pietroiusti, A; Sancesario, G; Lunardi, G; Fedele, E; Giacomini, P; Frasca, S; Galante, A; Marciani, MG; Stanzione, P;
Indirizzi:
Univ Roma Tor Vergata, Neurol Clin, Rome, Italy Univ Roma Tor Vergata Rome Italy Tor Vergata, Neurol Clin, Rome, Italy IRCCS Fdn S Lucia, I-00179 Rome, Italy IRCCS Fdn S Lucia Rome Italy I-00179 CS Fdn S Lucia, I-00179 Rome, Italy Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy Univ Roma Tor Vergata Rome Italy ergata, Dept Internal Med, Rome, Italy IST, Lab Pharmacol & Toxicol, Pharmacol & Neurosci Serv, Genoa, Italy ISTGenoa Italy acol & Toxicol, Pharmacol & Neurosci Serv, Genoa, Italy Dept Expt Med, Sect Pharmacol & Toxicol, Genoa, Italy Dept Expt Med Genoa Italy t Med, Sect Pharmacol & Toxicol, Genoa, Italy Univ Rome La Sapienza, Nervous & Mental Disorders Clin, Rome, Italy Univ Rome La Sapienza Rome Italy s & Mental Disorders Clin, Rome, Italy Univ Roma Tor Vergata, Dept Anesthesiol & Reanimat, Rome, Italy Univ Roma Tor Vergata Rome Italy pt Anesthesiol & Reanimat, Rome, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 89 - 91
SICI:
1590-1874(200102)22:1<89:RLAAIC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERADICATION; GASTRITIS; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Stanzione, P Univ Roma Tor Vergata, Neurol Clin, Rome, Italy Univ Roma TorVergata Rome Italy Neurol Clin, Rome, Italy
Citazione:
M. Pierantozzi et al., "Reduced L-dopa absorption and increased clinical fluctuations in Helicobacter pylori-infected Parkinson's disease patients", NEUROL SCI, 22(1), 2001, pp. 89-91

Abstract

We report that the area under the curve of L-dopa plasma concentration, following the administration of a single 250 mg L-dopa dose, is augmented after Helicobacter pylori (HP) eradication in six Parkinson's disease (PD) patients showing high IgG antibody titer against HP. A prolongation of L-dopa clinical benefit was also observed. We suggest that HP infection-activated gastric alterations may be responsible, at least in pare, for the reported erratic efficacy of oral L-dopa therapy in some advanced PD patients. Giventhe high percentage of HP-positivity in the age cohorts including the largest prevalence of PD patients, we propose that HP eradication be recommended in all PD patients under L-dopa therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:06:25