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Titolo:
Interaction between dopamine and adenosine A(2A) receptors as a basis for the treatment of Parkinson's disease
Autore:
Morelli, M; Pinna, A;
Indirizzi:
Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 pt Toxicol, I-09124 Cagliari, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 71 - 72
SICI:
1590-1874(200102)22:1<71:IBDAAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; TURNING BEHAVIOR; RATS; ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Pinna, A Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 l, I-09124 Cagliari, Italy
Citazione:
M. Morelli e A. Pinna, "Interaction between dopamine and adenosine A(2A) receptors as a basis for the treatment of Parkinson's disease", NEUROL SCI, 22(1), 2001, pp. 71-72

Abstract

The adenosine A(2A) receptor antagonist SCH 58261 increases the turning behaviour induced by L-dopa in unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats. In this study vie have evaluated the effect of a chronic intermittent administration of L-dopa or SCH 58261 plus L-dopa on turning behaviour. Chronic intermittent administration of SCH 58261 plus L-dopa produced a stable turning behaviour during the course of the treatment, whereas L-dopa alone produced a progressive increase in turning behaviour. Moreover, repeated administration of SCH 58261 failed to produce tolerance to its ability to potentiate L-dopa-induced turning behaviour. The results indicate that SCH 58261 is effective after chronic administration and suggest that SCH 58261 plus L-dopa, differently from L-dopa alone, does not produce alterations in motor responses during the course of the treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:38:59