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Titolo:
An abnormal striatal synaptic plasticity may account for the selective neuronal vulnerability in Huntington's disease
Autore:
Centonze, D; Gubellini, P; Picconi, B; Saulle, E; Tolu, M; Bonsi, P; Giacomini, P; Calabresi, P;
Indirizzi:
Univ Roma Tor Vergata, Dept Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy Univ Rome La Sapienza, Neurol Clin 2, Rome, Italy Univ Rome La Sapienza Rome Italy a Sapienza, Neurol Clin 2, Rome, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 61 - 62
SICI:
1590-1874(200102)22:1<61:AASSPM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Calabresi, P Univ Roma Tor Vergata, Dept Neurosci, Neurol Clin, Via Tor Vergata 135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133
Citazione:
D. Centonze et al., "An abnormal striatal synaptic plasticity may account for the selective neuronal vulnerability in Huntington's disease", NEUROL SCI, 22(1), 2001, pp. 61-62

Abstract

A marked decrease in the activity of mitochondrial complex II (succinate dehydrogenase, SD) has been found in the brains of Huntington's disease (HD)patients. Here we have examined the possibility that SD inhibitors might produce their toxic action by increasing corticostriatal glutamatergic transmission. We report that SD inhibitors produce a durable augmentation of NMDA-mediated corticostriatal excitation (DANCE) in striatal spiny neurons, but not in striatal cholinergic interneurons. DANCE involves increased intracellular calcium, activation of MAP kinase ERK and is critically dependent upon endogenous dopamine (DA) acting via D2-1ike receptors. This pathological form of corticostriatal synaptic plasticity might play a key role in the regional and cell-type specific neuronal death observed in HD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:21:27