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Titolo:
Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease
Autore:
Antonini, A; De Notaris, R; Benti, R; De Gaspari, D; Pezzoli, G;
Indirizzi:
Ist Clin Perfezionamento, Dept Neurosci, Parkinsons Dis Ctr, Milan, Italy Ist Clin Perfezionamento Milan Italy , Parkinsons Dis Ctr, Milan, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 45 - 46
SICI:
1590-1874(200102)22:1<45:PEITCO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEWY BODIES; DEMENTIA; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Antonini, A Ist Clin Perfezionamento, Dept Neurosci, Parkinsons Dis Ctr, Milan, Italy Ist Clin Perfezionamento Milan Italy Dis Ctr, Milan, Italy
Citazione:
A. Antonini et al., "Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease", NEUROL SCI, 22(1), 2001, pp. 45-46

Abstract

Cognitive abnormalities have been reported in a large percentage of patients with Parkinson's disease (PD). Often cognitive changes are sub-clinical and involve frontal lobe function. In other occasions they develop into full dementia. Functional neuroimaging may help characterize these abnormalities. We have studied brain perfusion with SPECT and the tracer ECD in 44 PD patients, 22 presenting with normal cognitive function and 22 with clinicaland neuropsychological signs of dementia. Compared with 21 healthy controls, demented PD patients showed significant perfusion decrements in all cortical areas, particularly temporal and parietal regions; in the non-dementedcohort reductions were limited to the frontal lobe area. These results suggest that brain perfusion abnormalities are present in PD patients. It is speculated that different pathological mechanisms underlie perfusion differences.

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Documento generato il 17/09/19 alle ore 22:39:13