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Titolo:
Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy
Autore:
Salmaggi, A; Maccagnano, E; Castagna, A; Zeni, S; Fantini, F; Cinque, P; Savoiardo, M;
Indirizzi:
Natl Neurol Inst C Besta, I-20133 Milan, Italy Natl Neurol Inst C Besta Milan Italy I-20133 Besta, I-20133 Milan, Italy Gaetano Pini Orthoped Inst, Milan, Italy Gaetano Pini Orthoped Inst Milan Italy Pini Orthoped Inst, Milan, Italy Univ Milan, Osped San Raffaele, IRCCS, I-20127 Milan, Italy Univ Milan Milan Italy I-20127 San Raffaele, IRCCS, I-20127 Milan, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 17 - 20
SICI:
1590-1874(200102)22:1<17:ROCPFJ>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; CENTRAL-NERVOUS-SYSTEM; HIV-INFECTED PATIENTS; CEREBROSPINAL-FLUID; DIAGNOSIS; AIDS; IMMUNODEFICIENCY; CYTARABINE; HAART;
Keywords:
SLE; PML; JC virus genome; cerebrospinal fluid; cidofovir;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Salmaggi, A Natl Neurol Inst C Besta, Via Celoria 2, I-20133 Milan, Italy Natl Neurol Inst C Besta Via Celoria 2 Milan Italy I-20133 ly
Citazione:
A. Salmaggi et al., "Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy", NEUROL SCI, 22(1), 2001, pp. 17-20

Abstract

We report the case of a 36-year-old woman affected by systemic lupus erythematosus who developed rapidly progressive multifocal leukoencephalopathy. Cidofovir therapy induced disappearance of JC virus genome from the cerebrospinal fluid and stabilization of the MRI picture. Despite the fatal outcome after a few months of disease, cidofovir treatment deserves further testing as single antiviral therapy in HIV-negative PML patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:41:51