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Titolo:
Cell encapsulation technology as a therapeutic strategy for CNS malignancies
Autore:
Visted, T; Bjerkvig, R; Enger, PO;
Indirizzi:
Univ Bergen, Dept Anat & Cell Biol, Lab Neurooncol, N-5009 Bergen, Norway Univ Bergen Bergen Norway N-5009 , Lab Neurooncol, N-5009 Bergen, Norway
Titolo Testata:
NEURO-ONCOLOGY
fascicolo: 3, volume: 3, anno: 2001,
pagine: 201 - 210
SICI:
1522-8517(200107)3:3<201:CETAAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALGINATE POLYCATION MICROCAPSULES; PLACEBO-CONTROLLED TRIAL; GENE-THERAPY; INTERSTITIAL CHEMOTHERAPY; MICROENCAPSULATED ISLETS; HUNTINGTONS-DISEASE; PANCREATIC-ISLETS; MANNURONIC ACID; GROWTH-FACTOR; DOUBLE-BLIND;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Visted, T Univ Bergen 19, Dept Anat & Cell Biol, N-5019 Bergen, Norway Univ Bergen 19 Bergen Norway N-5019 iol, N-5019 Bergen, Norway
Citazione:
T. Visted et al., "Cell encapsulation technology as a therapeutic strategy for CNS malignancies", NEURO-ONCOL, 3(3), 2001, pp. 201-210

Abstract

Gene therapy using viral vectors has to date failed to reveal its definitive clinical usefulness. Cell encapsulation technology represents an alternative, nonviral approach for the delivery of biologically active compounds to tumors, This strategy involves the use of genetically engineered producercells that secrete a protein with therapeutic potential. The cells are encapsulated in an immunoisolating material that makes them suitable for transplantation. The capsules, or bioreactors, permit the release of recombinantproteins that may assert their effects in the tumor microenvironment. During the last decades, there has been significant progress in the developmentof encapsulation technologies that comprise devices for both macro- and microencapsulation, The polysaccharide alginate is the most commonly used material for cell encapsulation and is well tolerated by various tissues. A wide spectrum of cells and tissues has been encapsulated and implanted, both in animals and humans, indicating the general applicability of this approach for both research and medical purposes, including CNS malignancies. Gliomas most frequently recur at the resection site, To provide local and sustained drug delivery, the bioreactors can be implanted in the brain parenchymaor in the ventricular system. The development of comprehensive analyses ofgeno- and phenotypic profiles of a tumor (genomics and proteomics) may provide new and important guidelines for choosing the optimal combination of bioreactors and recombinant proteins for therapeutic use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:40:16