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Titolo:
Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: From the First International CNS Germ-Cell Tumor Study
Autore:
Sands, SA; Kellie, SJ; Davidow, AL; Diez, B; Villablanca, J; Weiner, HL; Pietanza, MC; Balmaceda, C; Finlay, JL;
Indirizzi:
NYU, Hassenfeld Canc Ctr, Sch Med, Dept Psychiat, New York, NY 10016 USA NYU New York NY USA 10016 Sch Med, Dept Psychiat, New York, NY 10016 USA NYU, Sch Med, Dept Pediat, New York, NY 10016 USA NYU New York NY USA 10016 U, Sch Med, Dept Pediat, New York, NY 10016 USA Childrens Hosp Westmead, Sydney, NSW 2156, Australia Childrens Hosp Westmead Sydney NSW Australia 2156 ey, NSW 2156, Australia Univ Sydney, Sydney, NSW 2156, Australia Univ Sydney Sydney NSW Australia2156 Sydney, Sydney, NSW 2156, Australia Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Prevent Med & Community Hlth, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 Hlth, Newark, NJ 07103 USA Gutierrez Childrens Hosp, RA-1425 Buenos Aires, DF, Argentina Gutierrez Childrens Hosp Buenos Aires DF Argentina RA-1425 DF, Argentina Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles Los Angeles CA USA 90027 Angeles, CA 90027 USA State Univ New York, Brooklyn, NY 11203 USA State Univ New York Brooklyn NY USA 11203 ew York, Brooklyn, NY 11203 USA Columbia Presbyterian Med Ctr, Inst Neurol, New York, NY 10032 USA Columbia Presbyterian Med Ctr New York NY USA 10032 ew York, NY 10032 USA
Titolo Testata:
NEURO-ONCOLOGY
fascicolo: 3, volume: 3, anno: 2001,
pagine: 174 - 183
SICI:
1522-8517(200107)3:3<174:LQOLAN>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; PRIMITIVE NEUROECTODERMAL TUMORS; DOSE CRANIOSPINAL IRRADIATION; CHRONICALLY ILL CHILDREN; BRAIN-TUMORS; INTRACRANIAL GERMINOMA; PINEAL REGION; OF-LIFE; CRANIAL IRRADIATION; POSTERIOR-FOSSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Sands, SA NYU, Hassenfeld Canc Ctr, Sch Med, Dept Psychiat, 317 E 34th St,New York,NY 10016 USA NYU 317 E 34th St New York NY USA 10016 t, New York,NY 10016 USA
Citazione:
S.A. Sands et al., "Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: From the First International CNS Germ-Cell Tumor Study", NEURO-ONCOL, 3(3), 2001, pp. 174-183

Abstract

This study evaluated the quality of life and neuropsychologic functioning among patients enrolled between 1989 and 1993 in the First International CNS Germ-Cell Tumor Study. Quality-of-life questionnaires (Short Form-36 or Child Health Questionnaire) were completed on 43 patients at median follow-up of 6.1 years after diagnosis (range, 4.5-8.8 years), and intellectual andacademic testing was performed on 22 patients. Psychosocial and physical functioning of patients aged 19 years and older at follow-up was within the average range, whereas the same functioning for patients aged 18 years and younger, as reported by their parents at follow-up, was low average and borderline, respectively. Overall psychosocial and physical health summary scores were positively correlated with age at diagnosis for both groups combined. Those who received CNS radiation therapy (n = 29) reported significantly worse physical health, but similar psychosocial health, compared with those treated without radiation. Neuropsychologic testing indicated full-scaleand verbal IQ, reading, spelling, and math skills in the average range, and performance IQ in the low average range. Intelligence and math skills were positively correlated with age at diagnosis. Those with germinomas significantly outperformed those with nongerminomatous/mixed tumors on all neuropsychological measures administered. Younger patients diagnosed with CNS germ-cell tumors are at increased risk for psychosocial and physical problems as well as neuropsychologic deficits. Exposure to irradiation adversely affects overall physical functioning, whereas tumor pathology appears to be a salient neurocognitive risk factor. Collaborative and randomized studies are required to further elucidate the late effects arising from factors such as age at diagnosis, tumor histology, level of irradiation therapy, and chemotherapy toxicity among these young and potentially curable patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:23:03