Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARISON OF PHARMACOKINETICS AND DYNAMICS OF 2 DOSAGE REGIMENS OF FOSCARNET IN AIDS PATIENTS WITH CYTOMEGALOVIRUS RETINITIS
Autore:
CASTELLI F; TOMASONI L; ZEROLI C; SUTER F; TRESPI G; CAROSI G; HEDMAN A;
Indirizzi:
ASTRA RES CTR AB,DEPT CLIN PHARMACOL S-15185 SODERTALJE SWEDEN ASTRA RES CTR AB,DEPT CLIN PHARMACOL S-15185 SODERTALJE SWEDEN ASTRA FARMACEUT,DEPT MED MILAN ITALY SPEDALI CIVIL BRESCIA,DIV INFECT DIS 2 I-25125 BRESCIA ITALY UNIV BRESCIA,CLIN INFECT & TROP DIS BRESCIA ITALY
Titolo Testata:
European Journal of Clinical Pharmacology
fascicolo: 5, volume: 52, anno: 1997,
pagine: 397 - 401
SICI:
0031-6970(1997)52:5<397:COPADO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IMMUNODEFICIENCY VIRUS; PHOSPHONOFORMATE; NEPHROTOXICITY; HYPOCALCEMIA; PREVENTION; INFECTION; INFUSION;
Keywords:
FOSCARNET; HIV; CYTOMEGALOVIRUS (CMV); DOSAGE REGIMENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
F. Castelli et al., "COMPARISON OF PHARMACOKINETICS AND DYNAMICS OF 2 DOSAGE REGIMENS OF FOSCARNET IN AIDS PATIENTS WITH CYTOMEGALOVIRUS RETINITIS", European Journal of Clinical Pharmacology, 52(5), 1997, pp. 397-401

Abstract

Objective: To compare the pharmacokinetics of foscarnet administered as an infusion twice daily (BID) or thrice daily (TID), and to comparethe effects on the electrolyte balance, cardiac and renal functions over a 3-week induction treatment of Cytomegalovirus (CMV) retinitis. Methods: Pharmacokinetics/dynamics of foscarnet were investigated on treatment days 1, 14 and 21. Twelve AIDS patients with CMV retinitis completed the investigation period. Concentrations of foscarnet and electrolytes were assayed by high-performance liquid chromatography (HPLC) and by an ion-selective analyser, respectively. Results: The pharmacokinetics of the two regimens were essentially similar. Foscarnet plasmaand creatinine clearances were 2.0 and 1.6 ml.min(-1).kg(-1), respectively, in the BID group at steady state (day 21). In the TID group thecorresponding values were 1.8 and 1.7 ml.min(-1).kg(-1), respectively. In both regimens the elimination half-life of foscarnet was 2-3 h. Ionized calcium concentrations were transiently decreased and strongly inversely correlated to foscarnet plasma concentrations in both regimens with no significant differences between groups. A trend towards prolongation of the QTc interval was seen when data from both treatments were analysed together. Conclusion: Our data suggest comparable pharmacokinetics of foscarnet after intermittent administration BID or TID during a 3-week induction period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:38:46