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Titolo:
Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency
Autore:
Jiang, XC; Qin, SC; Qiao, CP; Kawano, K; Lin, M; Skold, A; Xiao, X; Tall, AR;
Indirizzi:
Columbia Univ, Dept Med, Div Mol Med, New York, NY 10027 USA Columbia Univ New York NY USA 10027 , Div Mol Med, New York, NY 10027 USA Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Biochem, Pittsburgh, PA 15261 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 7, volume: 7, anno: 2001,
pagine: 849 - 854
SICI:
1078-8956(200107)7:7<849:ABSAAA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE TRANSFER PROTEIN; HIGH-DENSITY LIPOPROTEINS; COMBINED HYPERLIPIDEMIA; TRANSGENIC MICE; HYPERTRIGLYCERIDEMIA; HYPERCHOLESTEROLEMIA; ABETALIPOPROTEINEMIA; MECHANISM; PARTICLES; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Tall, AR Columbia Univ, Dept Med, Div Mol Med, New York, NY 10027 USA Columbia Univ New York NY USA 10027 Med, New York, NY 10027 USA
Citazione:
X.C. Jiang et al., "Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency", NAT MED, 7(7), 2001, pp. 849-854

Abstract

Increased secretion and levels of ApoB-containing lipoproteins (BLp) commonly occur in familiar hyperlipidemia, obesity and diabetes. The plasma phospholipid-transfer protein (PLTP) is known to mediate transfer of phospholipids between BLp and HDL during their intravascular metabolism. To address apossible role of PLTP in dyslipidemia and atherogenesis, we bred mice deficient in the gene encoding PLTP (PLTP-deficient mice) using different hyperlipidemic mouse strains. In ApoB-transgenic and ApoE-deficient backgrounds,PLTP deficiency resulted in reduced production and levels of BLp and markedly decreased atherosclerosis. BLp secretion was diminished in hepatocytes from ApoB-transgenic PLTP-deficient mice, a defect that was corrected when PLTP was reintroduced in adenovirus. The studies reveal a major, unexpectedrole of PLTP in regulating the secretion of BLp and identify PLTP as a therapeutic target.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:39:27