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Titolo:
Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
Autore:
Heeschen, C; Jang, JJ; Weis, M; Pathak, A; Kaji, S; Hu, RS; Tsao, PS; Johnson, FL; Cooke, JP;
Indirizzi:
Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ardiovasc Med, Stanford, CA 94305 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 7, volume: 7, anno: 2001,
pagine: 835 - 841
SICI:
1078-8956(200107)7:7<835:NSAAPT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-ENDOTHELIAL-CELLS; ARTERIAL SMOOTH-MUSCLE; DNA-SYNTHESIS; NITRIC-OXIDE; MATRIX METALLOPROTEINASES; TRANSDERMAL NICOTINE; CIGARETTE-SMOKING; ACETYLCHOLINE; PROSTACYCLIN; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Cooke, JP Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Med, Stanford, CA 94305 USA
Citazione:
C. Heeschen et al., "Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis", NAT MED, 7(7), 2001, pp. 835-841

Abstract

We provide anatomic and functional evidence that nicotine induces angiogenesis. We also show that nicotine accelerates the growth of tumor and atheroma in association with increased neovascularization. Nicotine increased endothelial-cell growth and tube formation in vitro, and accelerated fibrovascular growth in vivo. In a mouse model of hind-limb ischemia, nicotine increased capillary and collateral growth, and enhanced tissue perfusion. In mouse models of lung cancer and atherosclerosis, we found that nicotine enhanced lesion growth in association with an increase in lesion vascularity. These effects of nicotine were mediated through nicotinic acetylcholine receptors at nicotine concentrations that are pathophysiologically relevant. The endothelial production of nitric oxide, prostacyclin and vascular endothelial growth factor might have a role in these effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:08:01