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Titolo:
Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli
Autore:
Springall, T; Sheerin, NS; Abe, K; Holers, VM; Wan, H; Sacks, SH;
Indirizzi:
Univ London Kings Coll, Dept Nephrol & Transplantat, Guys Hosp, GKT, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA Univ ColoradoDenver CO USA 80262 Sci Ctr, Dept Med, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Immunol, Denver, CO 80262 USA Univ London Kings Coll, Dept Cell & Mol Pathol, St Thomas Hosp, GKT,St Johns Inst Dermatol, London, England Univ London Kings Coll London England ns Inst Dermatol, London, England
Titolo Testata:
NATURE MEDICINE
fascicolo: 7, volume: 7, anno: 2001,
pagine: 803 - 808
SICI:
1078-8956(200107)7:7<803:ESOCPC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENT COMPONENT C3; EXPERIMENTAL PYELONEPHRITIS; MEDIATES STIMULATION; PROXIMAL TUBULE; HUMAN-KIDNEY; CELLS; EXPRESSION; MICE; GLOMERULONEPHRITIS; BIOSYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Sheerin, NS Univ London Kings Coll, Dept Nephrol & Transplantat, Guys Hosp, GKT, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS 2LS, England
Citazione:
T. Springall et al., "Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli", NAT MED, 7(7), 2001, pp. 803-808

Abstract

To assess the role of complement in renal infection, we studied a model ofEscherichia coli-induced pyelonephritis in mice deficient in complement components C3 and C4. Renal infection occurred less frequently in C3- and C4-deficient mice compared with wild-type mice. In vitro, renal epithelial cells internalized fewer bacteria in the absence of C3 or in the presence of blockade of C3 bound to the bacteria. Moreover, upregulation of epithelial C3 production by stimulation with lipopolysaccharide enhanced bacterial internalization. Here we provide evidence that uropathogenic E, coil might use host C3 to invade the renal epithelium and that local complement productionis sufficient for the bacteria to achieve this effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 00:44:09