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Titolo:
The essential role of MEKK3 in TNF-induced NF-kappa B activation
Autore:
Yang, JH; Lin, Y; Guo, ZJ; Cheng, JK; Huang, JY; Deng, L; Liao, W; Chen, ZJ; Liu, ZG; Su, B;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA UnivTexas Houston TX USA 77030 Ctr, Dept Immunol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Biochem & Mol Biol, Houston, TX 77030 USA NCI, Dept Cell & Canc Biol, Med Branch, Div Clin Sci,NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 ranch, Div Clin Sci,NIH, Bethesda, MD 20892 USA Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 d Ctr, Dept Mol Biol, Dallas, TX 75235 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 7, volume: 2, anno: 2001,
pagine: 620 - 624
SICI:
1529-2908(200107)2:7<620:TEROMI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CELL-DEATH; KINASE-ALPHA; INDUCED APOPTOSIS; RIP; BETA; IKK; PROTEIN; COMPLEX; PHOSPHORYLATION; RECRUITMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Su, B Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Dept Immunol, Houston, TX 77030 USA
Citazione:
J.H. Yang et al., "The essential role of MEKK3 in TNF-induced NF-kappa B activation", NAT IMMUNOL, 2(7), 2001, pp. 620-624

Abstract

Activation of I kappaB kinase (IKK) is the key step in stimulation of the transcription factor NF-kappaB, which regulates many genes in the inflammatory response pathway. The molecular mechanism that underlies IKK activationin response to tumor necrosis factor (TNF) is still unknown. Using mitogen-activated protein kinase kinase kinase 3 (MEKK3)-deficient fibroblast cells, we found that MEKK3 plays a critical role in TNF-induced NF-kappaB activation. We have shown that MEKK3 is required for IKK activation and functions downstream of receptor-interacting protein (RIP) and TNF receptor-associated factor 2. We have also shown that MEKK3 interacts with RIP and directlyphosphorylates IKK. The kinase activity of MEKK3 is pivotal to its function and, therefore, MEKK3 links RIP and IKK in TNF-induced NF-kappaB activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:44:11