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Titolo:
The costimulatory molecule ICOS plays an important role in immunopathogenesis of EAE
Autore:
Rottman, JB; Smith, T; Tonra, JR; Ganley, K; Bloom, T; Silva, R; Pierce, B; Gutierrez-Ramos, JC; Ozkaynak, E; Coyle, AJ;
Indirizzi:
Millennium Pharmaceut, Cambridge, MA 02139 USA Millennium Pharmaceut Cambridge MA USA 02139 eut, Cambridge, MA 02139 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 7, volume: 2, anno: 2001,
pagine: 605 - 611
SICI:
1529-2908(200107)2:7<605:TCMIPA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; ENCEPHALITOGENIC T-CELLS; IL-6-DEFICIENT MICE; CD28; ACTIVATION; RECEPTOR; DISEASE; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Rottman, JB Millennium Pharmaceut, 640 Mem Dr, Cambridge, MA 02139 USA Millennium Pharmaceut 640 Mem Dr Cambridge MA USA 02139 39 USA
Citazione:
J.B. Rottman et al., "The costimulatory molecule ICOS plays an important role in immunopathogenesis of EAE", NAT IMMUNOL, 2(7), 2001, pp. 605-611

Abstract

The inducible costimulatory molecule (ICOS) is expressed on activated T cells and participates in a variety of important immunoregulatory functions. After the induction of experimental allergic encephalomyelitis in SJL mice with proteolipid protein (PLP), brain ICOS mRNA and protein were up-regulated on infiltrating CD3(+) T cells before disease onset. ICOS blockade during the efferent immune response (9-20 days after immunization) abrogated disease, but blockade during antigen priming (1-10 days after immunization) exacerbated disease. Upon culture with PLP and compared with immunized controls, splenocytes produced either decreased interferon-gamma (IFN-gamma, in efferent blockade) or excessive IFN-gamma (in priming blockade). PLP-specific immunoglobulin GI was decreased in animals treated with anti-ICOS during antigen priming, but not in other groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:57:24