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Titolo:
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling
Autore:
Cavallaro, U; Niedermeyer, J; Fuxa, M; Christofori, G;
Indirizzi:
Res Inst Mol Pathol, A-1030 Vienna, Austria Res Inst Mol Pathol Vienna Austria A-1030 Pathol, A-1030 Vienna, Austria
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 7, volume: 3, anno: 2001,
pagine: 650 - 657
SICI:
1465-7392(200107)3:7<650:NMTATM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT NEURITE OUTGROWTH; ACTIVATED PROTEIN-KINASE; GROWTH-FACTOR RECEPTOR-4; NERVOUS-SYSTEM; IMMUNOGLOBULIN SUPERFAMILY; EXTRACELLULAR-MATRIX; SYNTHETIC PEPTIDES; PANCREATIC-ISLETS; POLYSIALIC ACID; NEURONAL CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Christofori, G Res Inst Mol Pathol, Dr Bohr Gasse 7, A-1030 Vienna, Austria Res Inst Mol Pathol Dr Bohr Gasse 7 Vienna Austria A-1030
Citazione:
U. Cavallaro et al., "N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling", NAT CELL BI, 3(7), 2001, pp. 650-657

Abstract

Loss of expression of neural cell-adhesion molecule (N-CAM) is implicated in the progression of tumour metastasis. Here we show that N-CAM modulates neurite outgrowth and matrix adhesion of beta -cells from pancreatic tumours by assembling a fibroblast-growth-factor receptor-4 (FGFR-4) signalling complex, which consists of N-cadherin, FGFR-4, phospholipase C gamma (PLC-gamma), the adaptor protein FRS2, pp60(c-src), cortactin and growth-associated protein-43 (GAP-43), Dominant-negative FGFR-4, inhibitors of FGFR signalling and anti-beta (1)-integrin antibodies repress matrix adhesion induced by N-CAM, FGF ligands can replace N-CAM in promoting matrix adhesion but notneurite outgrowth. The results indicate that N-CAM stimulates beta (1)-integrin-mediated cell-matrix adhesion by activating FGFR signalling. This is a potential mechanism for preventing the dissemination of metastatic tumourcells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:04:06