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Titolo:
Accumulation of mitochondrial DNA deletions in human oral tissues - effects of betel quid chewing and oral cancer
Autore:
Lee, HC; Yin, PH; Yu, TN; Chang, YD; Hsu, WC; Kao, SY; Chi, CW; Liu, TY; Wei, YH;
Indirizzi:
Natl Yang Ming Univ, Dept Biochem, Taipei 112, Taiwan Natl Yang Ming UnivTaipei Taiwan 112 , Dept Biochem, Taipei 112, Taiwan Natl Yang Ming Univ, Ctr Cellular & Mol Biol, Taipei 112, Taiwan Natl YangMing Univ Taipei Taiwan 112 lar & Mol Biol, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Inst Pharmacol, Taipei 112, Taiwan Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 112, Taiwan Taipei Vet Gen Hosp Taipei Taiwan 112 Med Res & Educ, Taipei 112, Taiwan Taipei Vet Gen Hosp, Dept Dent, Taipei 112, Taiwan Taipei Vet Gen Hosp Taipei Taiwan 112 osp, Dept Dent, Taipei 112, Taiwan
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 493, anno: 2001,
pagine: 67 - 74
SICI:
1383-5718(20010627)493:1-2<67:AOMDDI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LUNG TISSUES; ARECA NUT EXTRACT; OXIDATIVE STRESS; LIPID-PEROXIDATION; MUTATIONS; TUMORS; GENOME; DAMAGE; CARCINOGENESIS; INSTABILITY;
Keywords:
betel quid chewing; oral cancer; mitochondrial DNA deletions; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Wei, YH Natl Yang Ming Univ, Dept Biochem, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 iochem, Taipei 112, Taiwan
Citazione:
H.C. Lee et al., "Accumulation of mitochondrial DNA deletions in human oral tissues - effects of betel quid chewing and oral cancer", MUT RES-GTE, 493(1-2), 2001, pp. 67-74

Abstract

Accumulation of mitochondrial DNA (mtDNA) mutations in human tissues has been associated with intrinsic aging and environmental insult. Recently, mtDNA mutations have been detected in various tumors, including head and neck tumors. However, the factors affecting the occurrence and accumulation of mtDNA deletions in tumor tissues are poorly understood. In Taiwan, betel quid chewing is a major risk factor for oral cancer. Using polymerase chain reaction (PCR) techniques, we examined large-scale deletions of mtDNA in 53 pairs of tumor and non-tumor oral tissues from the patients with or without betel quid chewing history. The results revealed that irrespective of the history of betel quid chewing, the incidences of the 4977 bp deletion and other deletions of mtDNA were lower in the tumor portion as compared with thenon-tumor portion. The average proportions of the 4977 bp deleted mtDNA inthe tumor tissues of the betel quid chewers and non-betel quid chewers were 13- and 5-fold, respectively, lower than those in the corresponding non-tumor tissues. Moreover, the average proportion of 4977 bp deleted mtDNA wassignificantly higher (P < 0.05) in the non-tumor oral tissues of the patients with betel quid chewing history than that of the patients without the history of betel quid chewing. These results suggest that betel quid chewingmay increase mtDNA mutation in human oral tissues and that accumulation ofmtDNA deletions and subsequent cytoplasmic segregation of these mutations during cell division could be an important contributor to the early phase of oral carcinogenesis. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/03/20 alle ore 10:15:51