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Titolo:
Genotoxicity studies of three triazine herbicides: in vivo studies using the alkaline single cell gel (SCG) assay
Autore:
Tennant, AH; Peng, BC; Kligerman, AD;
Indirizzi:
US EPA, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA US EPARes Triangle Pk NC USA 27711 enesis, Res Triangle Pk, NC 27711 USA
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 493, anno: 2001,
pagine: 1 - 10
SICI:
1383-5718(20010627)493:1-2<1:GSOTTH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; MOUSE BONE-MARROW; COMET ASSAY; IN-VITRO; MAMMALIAN-CELLS; DNA-DAMAGE; ELECTROPHORESIS; MICRONUCLEUS; CYTOTOXICITY; INDUCTION;
Keywords:
triazines; DNA damage; herbicide; mouse; alkaline labile sites; electrophoresis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kligerman, AD US EPA, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 iangle Pk, NC 27711 USA
Citazione:
A.H. Tennant et al., "Genotoxicity studies of three triazine herbicides: in vivo studies using the alkaline single cell gel (SCG) assay", MUT RES-GTE, 493(1-2), 2001, pp. 1-10

Abstract

Triazine herbicides are prevalent contaminants of groundwater in the agricultural regions of the United States. The literature on the genotoxicity oftriazines is rife with conflicting data, though the general tendency is for most studies to report negative results. In order to investigate further the genotoxicity of triazines, we exposed mice to triazines by intraperitoneal injection up to the maximum tolerated doses. About 24h later, blood wasremoved, and the leukocytes subjected to DNA damage analysis using the alkaline single cell gel electrophoresis assay (SCG), one of the most sensitive DNA damage assays available. Our results indicate that atrazine induced asmall dose-related increase in DNA damage. Simazine did not induce any dose-related increase in DNA damage. Cyanazine induced a marginal increase in DNA damage with dose, but no individual dose was significantly increased compared to the control. These results indicate that these triazines, even atextremely high concentrations, have only marginal DNA-damaging activity invivo in mouse leukocytes. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:59:10