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Titolo:
Effect of monthly intravenous cyclophosphamide in rapidly deteriorating multiple sclerosis patients resistant to conventional therapy
Autore:
Khan, OA; Zvartau-Hind, M; Caon, C; Din, MU; Cochran, M; Lisak, D; Tselis, AC; Kamholz, JA; Garbern, JY; Lisak, RP;
Indirizzi:
Wayne State Univ, Sch Med, Dept Neurol, Multiple Sclerosis Ctr, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 clerosis Ctr, Detroit, MI 48201 USA
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 185 - 188
SICI:
1352-4585(200106)7:3<185:EOMICI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE CYCLOPHOSPHAMIDE/METHYLPREDNISOLONE; DISEASE; IMMUNOSUPPRESSION; INTERLEUKIN-12; MULTICENTER; DISABILITY; CRITERIA; MRI;
Keywords:
immunosuppressive therapy; progressive multiple sclerosis; cyclophosphamide; corticosteroids; immunomodulating therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Khan, OA 8D Univ Hlth Ctr, Dept Neurol, 4201 St Antoine, Detroit, MI 48201USA 8D Univ Hlth Ctr 4201 St Antoine Detroit MI USA 48201 I 48201 USA
Citazione:
O.A. Khan et al., "Effect of monthly intravenous cyclophosphamide in rapidly deteriorating multiple sclerosis patients resistant to conventional therapy", MULT SCLER, 7(3), 2001, pp. 185-188

Abstract

Fourteen consecutive clinically definite relapsing-remitting multiple sclerosis (MS) patients were treated with monthly intravenous cyclophosphamide (CTX) for 6 months. All had experienced severe clinical deterioration during the 12 months prior to treatment with CTX despite treatment with conventional immunomodulating agents and intravenous methylprednisolone. Treatment with CTX led to improvement and neurologic stability within 6 months which was sustained for at least 18 months after the onset of treatment with CTX. Therapy with CTX was well tolerated. CTX may be of benefit in MS patients who experience rapid clinical worsening and ore resistant to conventional therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 08:53:15