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Titolo:
Similar pro- and anti-inflammatory cytokine production in the different clinical forms of multiple sclerosis
Autore:
Duran, I; Martinez-Caceres, EM; Brieva, L; Tintore, M; Montalban, X;
Indirizzi:
Hosp Gen Valle Hebron, Serv Neurol, Unitat Neuroimmunol Clin, E-08035 Barcelona, Spain Hosp Gen Valle Hebron Barcelona Spain E-08035 , E-08035 Barcelona, Spain
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 151 - 156
SICI:
1352-4585(200106)7:3<151:SPAACP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MESSENGER-RNA EXPRESSION; NECROSIS-FACTOR-ALPHA; PRIMARY PROGRESSIVE DISEASE; SOLUBLE ADHESION MOLECULES; INTERFERON-GAMMA; PERIPHERAL-BLOOD; PROINFLAMMATORY CYTOKINE; FLOW-CYTOMETRY;
Keywords:
multiple sclerosis; primary progressive; cytokines; pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Montalban, X Escola Infermeria 5 Planta, Unitat Neuroimmunol Clin, Psg Vall Hebron 119-129, Barcelona 08035, Spain Escola Infermeria 5 Planta Psg Vall Hebron 119-129 Barcelona Spain 08035
Citazione:
I. Duran et al., "Similar pro- and anti-inflammatory cytokine production in the different clinical forms of multiple sclerosis", MULT SCLER, 7(3), 2001, pp. 151-156

Abstract

Cytokines ploy on important role in the initiation and maintenance of the inflammatory reaction in multiple sclerosis, a chronic inflammatory demyelinating disease of the central nervous system. Magnetic resonance imaging evidence supports clinical divergence between forms of multiple sclerosis with relapses and the primary progressive form without relapses which shows fewer and smeller inflammatory lesions. With the aim of understanding better the relative role of pro-inflammatory ond/or anti-inflammatory cytokines inprimary progressive multiple sclerosis in comparison to relapsing forms weanalysed in 65 patients (24 primary progressive, 20 relapsing-remitting and 21 secondary progressive) and 29 healthy controls, the Production of cytokines (IFN-gamma TNF-alpha, IL-6, IL-10 and IL- 12) by peripheral blood mononuclear cells after in vitro stimulation. We found a similar percentage ofcytokines producing cells between healthy controls and the different clinical forms of multiple sclerosis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:16:09