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Titolo:
Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease
Autore:
Killestein, J; Den Drijver, BF; Van der Graaff, WL; Uitdehaag, BMJ; Polman, CH; Van Lier, RAW;
Indirizzi:
VU Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands VU Med Ctr Amsterdam Netherlands NL-1007 MB 07 MB Amsterdam, Netherlands CLB, Dept Clin Viroimmunol, NL-1066 CX Amsterdam, Netherlands CLB Amsterdam Netherlands NL-1066 CX , NL-1066 CX Amsterdam, Netherlands
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 145 - 150
SICI:
1352-4585(200106)7:3<145:ICPITS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULES; INTERFERON-GAMMA; PERIPHERAL-BLOOD; FLOW-CYTOMETRY; MS; HETEROGENEITY; RESPONSES; PATHOGENESIS; SECRETION; PATHOLOGY;
Keywords:
T cells; cytokines; primary progressive MS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Killestein, J VU Med Ctr, Dept Neurol, POB 7057, NL-1007 MB Amsterdam, Netherlands VU Med Ctr POB 7057 Amsterdam Netherlands NL-1007 MB rlands
Citazione:
J. Killestein et al., "Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: different features in primary progressive disease", MULT SCLER, 7(3), 2001, pp. 145-150

Abstract

Objective: To evaluate the expression of cytokines in both CD4(+) and CD8() T cells derived from peripheral blood of untreated multiple sclerosis (MS) patients with either relapsing-remitting (RR), secondary progressive (SP) or primary progressive (PP) MS and healthy controls (HC). Background MS is on immune-mediated disease and cytokines have been hypothesized to contribute significantly to disease progression. Compared to the relapse-onset (RR, SP) form of the disease, PPMS patients have different clinical, immunological and pathological features. Surprisingly, the ability of their circulating T cells to Produce immunoregulatory cytokines has not been extensivelystudied so for. Methods: Seventy-two MS patients (24 RR, 26 SP, 22 PP) and34 HC were studied. Stimulated peripheral blood derived CD4(+) and CD8(+) T cells were analyzed for IFN-gamma, IL-2, TNF-alpha IL-4, IL-10 and IL-13 production. Results: MS patients express significantly more CD4(+) and CD8() T cells producing IFN-gamma compared to HC. Compared to the other forms of the disease, PPMS patients display a significant decrease in CD4(+) T cells producing IL-2, IL-13 and TNF-alpha and a significant increase in CD8(+) T cells producing IL-4 and IL-10. Conclusions: The data presented here demonstrate that patients with PPMS express less pro- and more anti-inflammatory cytokine producing T cells compared to the relapse-onset form of the disease, confirming the view on PPMS as a distinct disease entity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:43:10