Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gene expression in atherosclerotic lesion of ApoE deficient mice
Autore:
Wuttge, DM; Sirsjo, A; Eriksson, P; Stemme, S;
Indirizzi:
Karolinska Hosp, Dept Med, Ctr Mol Med, Cardiovasc Res Unit, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Unit, S-17176 Stockholm, Sweden Karolinska Hosp, Dept Med, King Gustaf V Res Inst, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Inst, S-17176 Stockholm, Sweden
Titolo Testata:
MOLECULAR MEDICINE
fascicolo: 6, volume: 7, anno: 2001,
pagine: 383 - 392
SICI:
1076-1551(200106)7:6<383:GEIALO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; SMOOTH-MUSCLE CELLS; MESSENGER-RNA; INFLAMMATORY DISEASE; APOLIPOPROTEIN-E; LYMPHOCYTES-T; MOUSE MODELS; MONOCYTE; MACROPHAGES; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Stemme, S Karolinska Hosp, Dept Med, Ctr Mol Med, Cardiovasc Res Unit, L8-03, S-17176 Stockholm, Sweden Karolinska Hosp L8-03 Stockholm Sweden S-17176 tockholm, Sweden
Citazione:
D.M. Wuttge et al., "Gene expression in atherosclerotic lesion of ApoE deficient mice", MOL MED, 7(6), 2001, pp. 383-392

Abstract

Background: Atherosclerosis, the major cause of mortality and invalidity in industrialized countries, is a multifactorial disease associated with high plasma cholesterol levels and inflammation in the vessel wall. Many different genes have previously been demonstrated in atherosclerosis, although limited numbers of genes are dealt with in each study. In general, data on dynamic gene expression during disease progress is limited and large-scale evaluation of gene expression patterns during atherogenesis could lead to a better understanding of the key events in the pathogenesis of atherosclerosis. We have therefore applied a mouse gene filter array to analyze gene expression in atherosclerotic ApoE-deficient mice. Materials and Methods: ApoE-deficient mice were fed atherogenic western diet for 10 or 20 weeks and aortas isolated. C57BL/6 mice on normal chow wereused as controls. The mRNAs of 15 animals were pooled and hybridized onto commercially available Clontech mouse gene array filters. Results:The overall gene expression in the ApoE-deficient and control micecorrelated well at both time points. Gene expression profiling showed varying patterns including genes up-regulated at 10 or 20 weeks only. At 20 weeks of diet, an increasing number of up-regulated genes were found in ApoE-deficient mice. Conclusions: The gene expression in atherogenesis is not a linear process with a maximal expression at advanced lesion stage. Instead, several genes demonstrate a dynamic expression pattern with peaks at the intermediate lesions stage. Thus, detailed evaluation of gene expression at several time points should help understanding the development of atherosclerosis and establishment of preventive intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 23:36:30