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Titolo:
Oestriol and oestradiol increase cell to cell communication and connexin43protein expression in human myometrium
Autore:
Di, WL; Lachelin, GCL; McGarrigle, HHG; Thomas, NSB; Becker, DL;
Indirizzi:
Royal Free & Univ Coll London Med Sch, Dept Obstet & Gynaecol, London WC1E6HX, England Royal Free & Univ Coll London Med Sch London England WC1E 6HX X, England Royal Free & Univ Coll London Med Sch, Dept Haematol, London WC1E 6HX, England Royal Free & Univ Coll London Med Sch London England WC1E 6HX X, England Univ Coll London, Dept Anat & Dev Biol, London WC1E 6BT, England Univ CollLondon London England WC1E 6BT Biol, London WC1E 6BT, England
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 7, volume: 7, anno: 2001,
pagine: 671 - 679
SICI:
1360-9947(200107)7:7<671:OAOICT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP JUNCTION PROTEIN; UTERINE SMOOTH-MUSCLE; ESTRIOL PROGESTERONE RATIO; PRETERM LABOR; ESTROGEN-RECEPTOR; SALIVA ESTRIOL; PHOSPHORYLATION; TERM; GENE; LOCALIZATION;
Keywords:
connexin43; labour; myometrium; oestradiol; oestriol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Lachelin, GCL Royal Free & Univ Coll London Med Sch, Dept Obstet & Gynaecol, 88-96 Chenies Mews, London WC1E 6HX, England Royal Free & Univ Coll London Med Sch 88-96 Chenies Mews London England WC1E 6HX
Citazione:
W.L. Di et al., "Oestriol and oestradiol increase cell to cell communication and connexin43protein expression in human myometrium", MOL HUM REP, 7(7), 2001, pp. 671-679

Abstract

Oestradiol increases the protein expression of connexin43 (Cx43) gap junctions in myometrium but the effect of oestriol on gap junction expression has not been described previously. Oestriol is the most abundant free oestrogen in pregnant women and there is a marked surge in oestriol concentrationsbefore term and idiopathic preterm labour. In order to determine whether oestriol may have a physiological action on the myometrium, cultured human myometrial cells obtained from non-pregnant hysterectomy specimens were exposed to 10 nmol/l oestradiol or oestriol, Intercellular communication between myometrial cells was investigated by microinjection of confluent culturedcells with the gap junction-permeant tracer Cascade Blue, There was a progressive increase in coupling after exposure to oestradiol or oestriol (P < 0.0005), An increase in Cx43 protein expression was demonstrated by immunocytochemistry after 1 h (P < 0.01) and 3 days (P < 0.01) exposure, and by Western blotting after 1 h (P < 0.01) and 3 days (P < 0.05) exposure, to bothoestradiol and to oestriol, We conclude that oestriol increases gap junction communication in human myometrium by increasing gap junction expression. Elevated oestriol concentrations may thus play a role in the initiation oflabour in women, by increasing cell-cell communication in the myometrium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 01:36:54