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Titolo:
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A1*2
Autore:
Przygodzki, RM; Koss, MN; OLeary, TJ;
Indirizzi:
Armed Forces Inst Pathol, Dept Cellular Pathol & Genet, Rockville, MD 20850 USA Armed Forces Inst Pathol Rockville MD USA 20850 , Rockville, MD 20850 USA Armed Forces Inst Pathol, Dept Pulm Pathol, Rockville, MD 20850 USA Armed Forces Inst Pathol Rockville MD USA 20850 , Rockville, MD 20850 USA
Titolo Testata:
MOLECULAR DIAGNOSIS
fascicolo: 2, volume: 6, anno: 2001,
pagine: 109 - 115
SICI:
1084-8592(200106)6:2<109:P(ASCC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
K-RAS; CANCER SUSCEPTIBILITY; HUMAN CYP1A1; GENE; POLYMORPHISMS; POPULATION; P53; ADENOCARCINOMA; K-RAS-2; ASSOCIATION;
Keywords:
lung carcinoma; CYP1A1; KRAS; DNA mutation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Przygodzki, RM Armed Forces Inst Pathol, Dept Cellular Pathol & Genet, 1413 Res Blvd,Bldg101, Rockville, MD 20850 USA Armed Forces Inst Pathol 1413 Res Blvd,Bldg 101 Rockville MD USA 20850
Citazione:
R.M. Przygodzki et al., "Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A1*2", MOL DIAGN, 6(2), 2001, pp. 109-115

Abstract

Background: Pleomorphic carcinoma (PC) of the lung is an aggressive epithelial neoplasm composed of giant and/or spindle tumor cells and associated with short survival. Most patients are cigarette smokers. The tumor susceptibility gene P-450 1A1 (CYP1A1) is involved in the activation of polycyclic aromatic hydrocarbons, including benzo[a]pyrene, producing DNA-damaging epoxides that lead to G:C -->T:A point mutations. Isoleucine (Ile)-valine (Val) and Val-Val genotypes of the CYP1A1 exon 7 polymorphism are associated with an increased risk for lung cancer in certain populations. Methods and Results: We sought to determine whether 25 archival, formalin-fixed, paraffin-embedded PC samples had a modified CYP1A1 gene profile at exon 7 using allele-specific PCR amplification. KRAS mutation status was available for all samples. Previous investigations have shown 0.88 Ile-Ile, 0.12 Ile-Val, and rarely, Val-Val as normal baseline population frequencies. Conversely, the markedly different PC CYP1A1 population frequencies were more likely to have the heterozygote variant alleles: 0.24 (six cases, Ile-Ile) and 0.76 (19 cases, Ile-Val; P < .001). CYP1A1 genotypes were found to be similar in both tumor and nontumor samples in a given case. All KRAS-mutated cases were Ile-Val heterozygotes. Conclusion: The increased propensity for the variant CYP1A1 allele may be the contributing factor to PC pathogenesis and may also result from KRAS mutations in these tumors.

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Documento generato il 04/06/20 alle ore 01:28:31