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Titolo:
Approaches to define the role of SF-1 at different levels of the hypothalamic-pituitary-steroidogenic organ axis
Autore:
Bakke, M; Zhao, LP; Parker, KL;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Internal Med, Div Endocrinol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med, Div Endocrinol, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Pharmacol, Div Endocrinol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 acol, Div Endocrinol, Dallas, TX 75235 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 179, anno: 2001,
pagine: 33 - 37
SICI:
0303-7207(20010620)179:1-2<33:ATDTRO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR RECEPTOR; GENE; FACTOR-1; MICE;
Keywords:
steroidogenic factor 1 (SF-1); gonadotropins; tissue-specific knockout;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Parker, KL Univ Texas, SW Med Ctr, Dept Internal Med, Div Endocrinol, 5323Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 75235 USA
Citazione:
M. Bakke et al., "Approaches to define the role of SF-1 at different levels of the hypothalamic-pituitary-steroidogenic organ axis", MOL C ENDOC, 179(1-2), 2001, pp. 33-37

Abstract

Targeted gene disruption has produced knockout mice lacking the orphan nuclear receptor steroidogenic Factor 1 (SF-1). These SF-l knockout mice lacked adrenal glands and gonads, resulting in adrenocortical insufficiency and sex reversal of their internal and external genitalia. They also had impaired expression of pituitary gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-I at multiple levels of the hypothalamic-pituitary-steroidogenic tissue axis. Using the Cre-loxP system- we now have generated mice in which SF-1 is inactivated selectively inthe anterior pituitary;. These pituitary-specific SF-I knockout mice were sterile and failed to exhibit sexual maturation. Histologically. their gonads were markedly hypoplastic, weighing only similar to 5% of the gonads of wild-type mice. Consistent with an important role of SF-1 in gonadotropes. there were no cells in the pituitary gland that expressed either follicle-stimulating hormone (FSH) or luteinizing hormone (LH), These pituitary-specific SF-I knockout mice are a novel genetic model of hypogonadotropic hypogonadism and establish essential roles of SF-1 in gonadotropin expression. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 14:30:40