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Titolo:
Bacterial Ohr and OsmC paralogues define two protein families with distinct functions and patterns of expression
Autore:
Atichartpongkul, S; Loprasert, S; Vattanaviboon, P; Whangsuk, W; Helmann, JD; Mongkolsuk, S;
Indirizzi:
Chulabhorn Res Inst, Biotechnol Lab, Bangkok 10210, Thailand Chulabhorn Res Inst Bangkok Thailand 10210 Lab, Bangkok 10210, Thailand Mahidol Univ, Fac Sci, Dept Biotechnol, Bangkok 10400, Thailand Mahidol Univ Bangkok Thailand 10400 Biotechnol, Bangkok 10400, Thailand Cornell Univ, Dept Microbiol, Ithaca, NY 14853 USA Cornell Univ Ithaca NYUSA 14853 iv, Dept Microbiol, Ithaca, NY 14853 USA
Titolo Testata:
MICROBIOLOGY-SGM
, volume: 147, anno: 2001,
parte:, 7
pagine: 1775 - 1782
SICI:
1350-0872(200107)147:<1775:BOAOPD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKYL-HYDROPEROXIDE REDUCTASE; THIOL-SPECIFIC ANTIOXIDANT; AHPF-OXYR-ORFX; HYDROGEN-PEROXIDE; ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; GENE OSMC; BACILLUS-SUBTILIS; GENOME SEQUENCE; XANTHOMONAS;
Keywords:
Pseudomonas aeruginosa; Deinococcus radiodurans; organic peroxide; resistance; osmotic stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Mongkolsuk, S Chulabhorn Res Inst, Biotechnol Lab, Lak Si, Bangkok 10210, Thailand Chulabhorn Res Inst Lak Si Bangkok Thailand 10210 Thailand
Citazione:
S. Atichartpongkul et al., "Bacterial Ohr and OsmC paralogues define two protein families with distinct functions and patterns of expression", MICROBI-SGM, 147, 2001, pp. 1775-1782

Abstract

Xanthomonas campestris Ohr (a protein involved in organic peroxide protection) and Escherichia coli OsmC (an osmotically inducible protein of unknownfunction) are related proteins. Database searches and phylogenetic analyses reveal that Ohr and OsmC homologues cluster into two related subfamilies of proteins widely distributed in both Gram-negative and Grampositive bacteria. To determine if these two subfamilies are functionally distinct, ohr and osmC in Pseudomonas aeruginosa (a bacterium with one representative fromeach subfamily) were analysed. Only ohr mutants are hypersensitive to organic peroxide, and this phenotype can be restored by complementation with ohr but not osmC. In addition, expression of ohr ias highly induced only by organic peroxides, and not by other oxidants or stresses. In contrast, osmC was induced by ethanol and osmotic stress. A similar pattern of regulation was observed for Ohr and OsmC homologues in the Gram-positive bacterium Deinococcus radiodurans, though uninduced expression was much higher and induction lower in this species. These data clearly support the conclusion that Ohr and OsmC define two functionally distinct subfamilies with distinct patterns of regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:02:03