Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of absorbed components of Saiboku-to on the release of leukotrienes from polymorphonuclear leukocytes of patients with bronchial asthma
Autore:
Niitsuma, T; Morita, S; Hayashi, T; Homma, M; Oka, K;
Indirizzi:
Tokyo Med Univ, Dept Internal Med 3, Shinjuku Ku, Tokyo 160, Japan Tokyo Med Univ Tokyo Japan 160 rnal Med 3, Shinjuku Ku, Tokyo 160, Japan Tokyo Univ Pharm & Life Sci, Dept Clin Pharmacol, Tokyo, Japan Tokyo Univ Pharm & Life Sci Tokyo Japan pt Clin Pharmacol, Tokyo, Japan Univ Tsukuba, Inst Clin Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 n Med, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 2, volume: 23, anno: 2001,
pagine: 99 - 103
SICI:
0379-0355(200103)23:2<99:EOACOS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Keywords:
Kampo; leukotriene; leukotriene B-4; leukotriene C-4; Saiboku-to;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Niitsuma, T Tokyo Med Univ, Dept Internal Med 3, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 160, Japan Tokyo Med Univ 6-7-1 Nishishinjuku Tokyo Japan 160 160, Japan
Citazione:
T. Niitsuma et al., "Effects of absorbed components of Saiboku-to on the release of leukotrienes from polymorphonuclear leukocytes of patients with bronchial asthma", METH FIND E, 23(2), 2001, pp. 99-103

Abstract

Previous studies confirmed the efficacy of the Chinese herbal remedy Saiboku-to in patients with steroid-dependent asthma. We studied 8 phenolic compounds, isolated from the urine of patients receiving Saiboku-to, with respect to their effects on leukotriene (LT) release by polymorphonuclear leukocytes (PMN) obtained from 6 patients with atopic asthma and 8 healthy subjects. The compounds (0.01-10 mug/ml) were incubated with Ca2+ ionophore (A23187)-stimulated PMN, and concentrations of leukotriene B-4 (LTB4) and leukotreine C-4 (LTC4) in the supernatant were measured by EIA. Each compound suppressed the release of LTB4 and LTC4 by PMN obtained from healthy and asthmatic subjects. In particular, baicalein and magnolol were 5-10 times more potent than azelastine, an antiallergic drug, and significantly suppressed LTC4 release by PMN obtained from asthmatic patients, as compared with healthy subjects. Suppression of LTC4 release by these compounds may play an important role in the clinical efficacy of Saiboku-to. (C) 2001 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:45:13