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Titolo:
Sulfate could mediate the therapeutic effect of glucosamine sulfate
Autore:
Hoffer, LJ; Kaplan, LN; Hamadeh, MJ; Grigoriu, AC; Baron, M;
Indirizzi:
Sir Mortimer B Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada Sir Mortimer B Jewish Gen Hosp Montreal PQ Canada , Montreal, PQ, Canada Sir Mortimer B Jewish Gen Hosp, Div Rheumatol, Montreal, PQ, Canada Sir Mortimer B Jewish Gen Hosp Montreal PQ Canada , Montreal, PQ, Canada
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 7, volume: 50, anno: 2001,
pagine: 767 - 770
SICI:
0026-0495(200107)50:7<767:SCMTTE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INORGANIC SULFATE; ARTICULAR-CARTILAGE; CHONDROITIN SULFATE; SODIUM-SULFATE; SERUM SULFATE; OSTEOARTHRITIS; PHARMACOKINETICS; HYDROCHLORIDE; ACETAMINOPHEN; EXCRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Hoffer, LJ McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, 3755 Cote St Catherine Rd, Montreal, PQ H3T 1E2, Canada McGill Univ 3755 Cote St Catherine Rd Montreal PQ Canada H3T 1E2
Citazione:
L.J. Hoffer et al., "Sulfate could mediate the therapeutic effect of glucosamine sulfate", METABOLISM, 50(7), 2001, pp. 767-770

Abstract

Glucosamine sulfate is a controversial osteoarthritis remedy that is presumed to stimulate articular cartilage glycosaminoglycan synthesis by increasing glucosamine concentrations in the joint space. However, this is not plausible because even large oral doses of the product have no effect on serumglucosamine concentrations. We propose instead that sulfate could mediate the clinical benefit attributed to this treatment. Sulfate is required for glycosaminoglycan synthesis, and unlike glucosamine, its serum level can bemodified by dietary and other factors. In this study, we tested whether oral glucosamine sulfate increases serum sulfate concentrations and whether the sulfate concentration in the synovial fluid reflects that in the serum. The serum sulfate concentration of 7 normal subjects was 331 +/- 21 mu mol/L before ingestion of 1.0 g glucosamine sulfate and 375 +/- 17 mu mol/L 3 hours after [P < .05). Serum sulfate concentrations decreased from 325 +/- 19 to 290 +/- 19 mu mol/L when the same dose of glucosamine sulfate was ingested with 1.0 g of the analgesic drug acetaminophen, which is largely metabolized by sulfation (P < .05), Unlike glucosamine sulfate, oral sodium sulfate did not significantly increase the serum sulfate concentration. Synovial fluid and serum sulfate concentrations were closely similar when measuredin 15 patients undergoing diagnostic needle aspiration of a knee effusion (r = .99, slope = .97, P < .0001). These results do not prove that glucosamine sulfate improves osteoarthritis, but considered with other data, they do provide a plausible biochemical mechanism for its reported beneficial effects. This hypothesis is clinically relevant because it predicts that nonsulfate salts of glucosamine will be ineffective and that renal function, diet, and concurrent acetaminophen therapy could confound clinical trials of this therapy. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:31:01