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Titolo:
Influence of estrogen replacement therapy on plasma lipid peroxidation
Autore:
Gomez-Zubeldia, MA; Arbues, JJ; Hinchado, G; Nogales, AG; Millan, JC;
Indirizzi:
Univ Extremadura, Dept Nursing, Sch Med, E-06071 Badajoz, Spain Univ Extremadura Badajoz Spain E-06071 , Sch Med, E-06071 Badajoz, Spain Univ Extremadura, Sch Med, Dept Obstet & Gynecol, E-06071 Badajoz, Spain Univ Extremadura Badajoz Spain E-06071 & Gynecol, E-06071 Badajoz, Spain Univ Extremadura, Dept Math, E-06071 Badajoz, Spain Univ Extremadura Badajoz Spain E-06071 Dept Math, E-06071 Badajoz, Spain
Titolo Testata:
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 274 - 280
SICI:
1072-3714(200107/08)8:4<274:IOERTO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT ENZYME-ACTIVITIES; DNA-DAMAGE; MEDROXYPROGESTERONE-ACETATE; TRANSDERMAL ESTRADIOL; SUPEROXIDE-DISMUTASE; VASOMOTOR RESPONSES; HORMONE REPLACEMENT; PROLONGED EXERCISE; FREE-RADICALS; WISTAR RATS;
Keywords:
malondialdehyde; estradiol; catalase; superoxide dismutase; plasma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Gomez-Zubeldia, MA Fac Med, Area Obstet & Ginecol, Badajoz 06071, Spain Fac Med Badajoz Spain 06071 col, Badajoz 06071, Spain
Citazione:
M.A. Gomez-Zubeldia et al., "Influence of estrogen replacement therapy on plasma lipid peroxidation", MENOPAUSE, 8(4), 2001, pp. 274-280

Abstract

Objective: To observe whether any relationship exists between the concentration of plasma estradiol (E-2) and the plasma concentrations of malondialdehyde (MDA) or whether a relationship exists between the concentration of plasma E-2 and the activity of the erythrocyte enzymes, superoxide dismutase(SOD) and catalase, in ovariectomized female Wister rats (treated and untreated with E-2). Design: We used 40 ovariectomized Wistar rats randomly assigned to four groups. The first group was allowed to evolve freely with no treatment. A gelcontaining 17 beta -estradiol was administered transdermally to the other three groups at doses of 4, 8, and 16 mug/day, respectively. After 15 days of treatment, blood samples were obtained from the four groups. The concentrations of plasma MDA and E-2 and the activities of erythrocyte catalase and SOD were determined. Results: There were significant correlations between the MDA levels and the logarithm (base 10) of the plasma E-2 concentrations in both linear (p = 0.00093) and quadratic (p = 0.000001) regression analyses. No relationship was found between the E-2 concentrations and the catalase and SOD activities. Conclusions: There was a clear relationship between the plasma levels of MDA and the logarithm of the plasma E-2 concentrations, which was best demonstrated with a quadratic regression. This model may explain the contradictory findings presented by estrogens with respect to their pro- or antioxidant action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:18:40