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Titolo:
Continuous combined hormone replacement therapy with oral 17 beta-estradiol and norethisterone acetate improves homocysteine metabolism in postmenopausal women
Autore:
Ventura, P; Cagnacci, A; Malmusi, S; Panini, R; Baldassari, F; Arangino, S; Volpe, A; Salvioli, G;
Indirizzi:
Univ Modena, Dept Internal Med, Chair Geriatr & Gerontol, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 riatr & Gerontol, I-41100 Modena, Italy Univ Modena, Dept Gynaecol Obstet & Paediat Sci, Div Obstet & Gynaecol, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 bstet & Gynaecol, I-41100 Modena, Italy
Titolo Testata:
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 252 - 258
SICI:
1072-3714(200107/08)8:4<252:CCHRTW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; INDEPENDENT RISK FACTOR; PLASMA HOMOCYSTEINE; VASCULAR-DISEASE; QUANTITATIVE ASSESSMENT; SERUM HOMOCYSTEINE; MENOPAUSAL STATUS; HEART-DISEASE; HYPERHOMOCYST(E)INEMIA; HOMOCYST(E)INE;
Keywords:
homocysteine; HRT; transsulfuration; homocysteine-related vitamin status; sex hormone effects; vascular risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ventura, P Univ Modena, Dept Internal Med, Chair Geriatr & Gerontol, VialeV Veneto 9, I-41100 Modena, Italy Univ Modena Viale V Veneto 9 Modena Italy I-41100 odena, Italy
Citazione:
P. Ventura et al., "Continuous combined hormone replacement therapy with oral 17 beta-estradiol and norethisterone acetate improves homocysteine metabolism in postmenopausal women", MENOPAUSE, 8(4), 2001, pp. 252-258

Abstract

Objective: To evaluate the effect of a continuous combined oral hormone replacement therapy (HRT) on basal and post-methionine load homocysteine levels in postmenopausal women. Design: Twenty-two postmenopausal women (PMW) were randomly allocated to receive either continuous combined oral HRT (2 mg of estradiol plus 1 mg of norethisterone acetate; n = 11) or no treatment (controls, n = 11) for 6 months. A methionine oral load (0.1 g/kg body weight) was performed in each subject at time 0 and after 6 months. Serum homocysteine levels were measured by high-performance liquid chromatography in samples collected at time 0 and at 4, 8, and 24 h after the methionine load, while levels of vitamin B,(by high-performance liquid chromatography) and B,, and folate (both by ELISA) were assayed in samples collected at time 0. Results: Serum levels of glucose and body mass index increased in treated PMW, whereas folate decreased in controls. In treated PMW, basal homocysteine tended to decrease (10.6 +/- 3.3 mu mol/L vs. 9.62 +/- 2.8 mu mol/L, p =0.062), whereas in controls it significantly increased (10.7 +/- 2.65 mu mol/L vs. 12.17 +/- 3.89 mu mol/L, p < 0.05). This increase was not significant after correction for vitamin status (p = 0.072). Homocysteine values 4 h (31.9 +/- 13.53 mu mol/L vs. 39.83 +/- 22.53 mu mol/L, p < 0.05) and 8 h (35.1 +/- 13.13 vs. 43.34 +/- 22.15 mu mol/L) after methionine, and integrated homocysteine response to methionine (392.5 +/- 133.8 mu mol/24 h vs. 458.8 +/- 104.8 mu mol/24 h; p < 0.05), were significantly reduced in HRT-treated, but not in untreated, PMW. Conclusions: Continuous combined oral HRT with 17 beta -estradiol plus norethisterone acetate reduces homocysteine levels, mainly after a methionine load. This effect seems to be independent of vitamin status and may have positive implications for the prevention of cardiovascular diseases in PMW.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:51:29