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Titolo:
Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters - Relationships with impulsivity and depression
Autore:
Spreux-Varoquaux, O; Alvarez, JC; Berlin, I; Batista, G; Despierre, PG; Gilton, A; Cremniter, D;
Indirizzi:
Ctr Hosp Versailles, Serv Biochim Pharmacol, F-78157 Le Chesnay, France Ctr Hosp Versailles Le Chesnay France F-78157 F-78157 Le Chesnay, France Univ Paris 05, Fac Med Paris Ouest, F-75270 Paris 06, France Univ Paris 05 Paris France 06 Med Paris Ouest, F-75270 Paris 06, France Hop La Pitie Salpetriere, Paris, France Hop La Pitie Salpetriere Paris France Pitie Salpetriere, Paris, France Hop Henri Mondor, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 Mondor, F-94010 Creteil, France
Titolo Testata:
LIFE SCIENCES
fascicolo: 6, volume: 69, anno: 2001,
pagine: 647 - 657
SICI:
0024-3205(20010629)69:6<647:DAIP5A>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE-A; IMIPRAMINE BINDING; BRAIN-SEROTONIN; BEHAVIOR; TRANSPORTER; BLOOD; CLOMIPRAMINE; METABOLITES; INHIBITION; DISORDER;
Keywords:
blood; serotonin; 5-hydroxyindolacetic acid; violent suicide; impulsivity; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Spreux-Varoquaux, O Ctr Hosp Versailles, Serv Biochim Pharmacol, 177 Rue Versailles, F-78157 Le Chesnay, France Ctr Hosp Versailles 177 Rue Versailles Le Chesnay France F-78157
Citazione:
O. Spreux-Varoquaux et al., "Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters - Relationships with impulsivity and depression", LIFE SCI, 69(6), 2001, pp. 647-657

Abstract

Brain serotonergic systems may participate in the regulation of mood, impulsivity and aggressive behavior. Because some monoaminergic mechanisms seemto be similar in the central nervous system and peripheral tissues, we tested whether serotonergic or dopaminergic biochemical parameters in peripheral venous blood are related or not to violent suicide behavior. We simultaneously studied plasma serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and platelet 5-HT content in patients within 3 days following a violent suicide attempt and in matched healthy controls. We examined their relationship with depression and impulsivity. Twenty seven drug-free suicide at tempters and controls were included. Plasma 5-HIAA and platelet 5-HT concentrations were lower in suicide attempters than in controls. Fifteen patients were classified as impulsive (I), including all patients suffering from personality disorder and alcohol abuse, and 12 as non impulsive (NI), mostly melancholics. MADRS scores were similar in both I and NI suicide attempters. When controlling for age, plasma 5-HIAA was lower inI than in NI suicide attempters or controls; these findings are similar tothose we observed recently with CSF 5-HIAA in I and NI violent suicide attempters. Contrarily, platelet 5-HT levels were lower in NI than in I patients or controls. Plasma HVA was not associated with suicide behavior. Plasma5-HIAA concentration was inversely associated with the degree of impulsivity and platelet 5-HT with the intensity of depression. This study indicatesthat each peripheral serotonergic index is specifically related to a distinct clinical feature and shows differential alteration according to the impulsivity group. In I and NI drug-free violent suicide attempters an inversefigure between plasma 5-HIAA and platelet 5-HT data was observed indicating a non parallelism between these two peripheral variables. Further prospective studies are needed to investigate whether these peripheral serotonergic parameters may be used as helpful early predictors of violent suicide behavior. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 18/01/20 alle ore 11:09:59