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Titolo:
Verbal memory deficits associated with fornix atrophy in carbon monoxide poisoning
Autore:
Kesler, SR; Hopkins, RO; Weaver, LK; Blatter, DD; Edge-Booth, H; Bigler, ED;
Indirizzi:
Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA Brigham Young Univ Provo UT USA 84602 , Dept Psychol, Provo, UT 84602 USA LDS Hosp, Dept Radiol, Salt Lake City, UT USA LDS Hosp Salt Lake City UT USA Hosp, Dept Radiol, Salt Lake City, UT USA Univ Utah, Dept Med, Div Pulm, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Pulm, Salt Lake City, UT 84112 USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 640 - 646
SICI:
1355-6177(200107)7:5<640:VMDAWF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERBARIC-OXYGEN; QUANTITATIVE MRI; TEMPORAL-LOBE; BRAIN; AMNESIA; DAMAGE; TOMOGRAPHY; INJURY; INDEX; TRIAL;
Keywords:
carbon monoxide poisoning; morphometric analysis; fornix; neuropsychological outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Hopkins, RO Brigham Young Univ, Dept Psychol, 1001 SWKT, Provo, UT 84602 USA Brigham Young Univ 1001 SWKT Provo UT USA 84602 , UT 84602 USA
Citazione:
S.R. Kesler et al., "Verbal memory deficits associated with fornix atrophy in carbon monoxide poisoning", J INT NEURO, 7(5), 2001, pp. 640-646

Abstract

Magnetic resonance (MR) images and neuropsychological testing data of 69 carbon monoxide (CO) poisoned patients were prospectively obtained within I day of CO poisoning, two weeks and six months. CO patients' Day cross-sectional fornix surface area measurements, corrected for head size by using a fornix-to-brain ratio (FBR), were compared to normal age and gender-matched controls. Additionally, a within-subjects analysis was performed comparing the mean areas between CO patients' Day 1, 2 weeks and 6-month FBR. The FBRwas correlated with patients' neuropsychological data. There were no significant differences between CO patients' Day 1 fornix measurements compared to normal control subjects. However, significant atrophic changes in the fornix of CO poisoned patients occurred at two weeks with no progressive atrophy at 6 months. By 6 months, CO patients showed significant decline on tests of verbal memory (when practice effects were taken into account), whereas visual memory, processing speed and attention/concentration did not decline. This study indicates that CO results in brain damage and cognitive impairments in the absence of lesions and other neuroanatomic markers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 07:34:54