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Titolo:
Preclinical prediction of AD using neuropsychological tests
Autore:
Albert, MS; Moss, MB; Tanzi, R; Jones, K;
Indirizzi:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, Charlestown,MA 02129 USA Harvard Univ Charlestown MA USA 02129 Psychiat, Charlestown,MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA Harvard Univ Charlestown MA USA 02129 t Neurol, Charlestown, MA 02129 USA Boston Univ, Dept Anat & Neurobiol, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 pt Anat & Neurobiol, Boston, MA 02215 USA Brandeis Univ, Heller Sch Social Policy, Waltham, MA 02254 USA Brandeis Univ Waltham MA USA 02254 h Social Policy, Waltham, MA 02254 USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 631 - 639
SICI:
1355-6177(200107)7:5<631:PPOAUN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; MEMORY LOSS; QUESTIONABLE DEMENTIA; CINGULATE CORTEX; DEFICITS; DEGENERATION; DIAGNOSIS; ONSET;
Keywords:
preclinical Alzheimer's disease; memory; executive function; MCI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Albert, MS Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, Psychiat Gerontol 149-9124,149 13th St, Charlestown, MA 02129 USA Harvard Univ Psychiat Gerontol 149-9124,149 13th St Charlestown MA USA 02129
Citazione:
M.S. Albert et al., "Preclinical prediction of AD using neuropsychological tests", J INT NEURO, 7(5), 2001, pp. 631-639

Abstract

Normals (N = 42) and patients with mild memory difficulty (N = 123) were given a neuropsychological test battery, and then followed annually for 3 years to determine which individuals developed sufficient functional change that they met clinical criteria for AD. Twenty-three of the 123 participantswith mild memory difficulty converted to a diagnosis of probable Alzheimer's disease (AD) within 3 years of follow-up. Four of the 20 neuropsychological measures obtained at baseline, were useful in discriminating the groupson the basis of their status 3 years after the tests were given. The 4 discriminating tests pertained to assessments of memory and executive function. When the controls were compared to the individuals with memory impairments who ultimately developed AD (the converters), the accuracy of discrimination was 89%, based on the neuropsychological measures at baseline. The discrimination of the controls from the individuals with mild memory problems who did not progress to the point where they mel clinical criteria for probable AD over the 3 years of follow-up (the Questionables) was 74% and the discrimination of the questionables from the converters was 80%. The specifictests that contributed to these discriminations. in conjunction with recent neuropathological and neuroimaging data from preclinical cases, have implications for which brain regions may be affected during the prodromal phaseof AD.

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Documento generato il 19/01/20 alle ore 14:36:58