Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Where and what visuospatial processing in adolescents with congenital hypothyroidism
Autore:
Leneman, M; Buchanan, L; Rovet, J;
Indirizzi:
Univ Ottawa, Sch Med, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Sch Med, Ottawa, ON K1N 6N5, Canada Univ Alberta, Dept Psychol, Edmonton, AB, Canada Univ Alberta Edmonton ABCanada erta, Dept Psychol, Edmonton, AB, Canada Univ Toronto, Dept Pediat, Toronto, ON, Canada Univ Toronto Toronto ON Canada Toronto, Dept Pediat, Toronto, ON, Canada
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 556 - 562
SICI:
1355-6177(200107)7:5<556:WAWVPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GENICULATE-NUCLEUS; EXTRASTRIATE CORTEX; THYROID-HORMONES; VISUAL PATHWAYS; TURNER-SYNDROME; NERVOUS-SYSTEM; GANGLION-CELLS; RHESUS-MONKEY; CHILDREN; BRAIN;
Keywords:
visuospatial ability; visual cortex; neuroanatomic pathways; congenital hypothyroidism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Rovet, J Hosp Sick Children, Brain & Behav Program, 555 Univ Ave, Toronto,ON M5G 1X8, Canada Hosp Sick Children 555 Univ Ave Toronto ON Canada M5G 1X8 Canada
Citazione:
M. Leneman et al., "Where and what visuospatial processing in adolescents with congenital hypothyroidism", J INT NEURO, 7(5), 2001, pp. 556-562

Abstract

Visuospatial processing is accomplished in distinct neuroanatomic pathways. One such pathway, known as the where pathway, involves a dorsal route through magnocellular thalamic cells to occipital and parietal cortices and conveys location and motion information. A second pathway, known as the It what pathway, involves a ventral route through parvocellular thalamic cells to occipital and temporal cortices and conveys color and form information. The where pathway is thought to he responsible for processing spatial relationships while the what pathway is responsible for object identification. Children with early-treated congenital hypothyroidism (CH) who exhibit selective visuospatial deficits may provide a good model to study the differential development of these pathways. Because children with CH lacked thyroid hormone at a time when needed by developing brain regions such as the parietal cortex, these children may be affected to a greater degree on tasks tapping where but not what pathway processing. We tested this hypothesis via retrospective analysis of their performance on 6 spatial tasks. Compared were 49 adolescents with CH and 49 matched control participants. On the basis ofconfirmatory factor analysis, tasks were assigned to either where or what pathway groupings. A repeated measures ANOVA showed the CH group was impaired relative to a normal comparison group only on where pathway tasks. Regression analyses indicated that severity of early hypothyroidism was the strongest predictor of M here pathway processing but had no effect on what pathway tasks. It is concluded that thyroid hormone is required during late gestation and early life for the normal development of the where aspects of visuospatial processing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 21:08:43