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Titolo:
Association of HLA class II genes with systemic sclerosis in Koreans
Autore:
Kang, SH; Park, MH; Song, EY; Kang, SJ; Lee, EB; Song, YW; Takeuchi, F;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Clin Pathol, Chongno Gu, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 o Gu, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Internal Med, Chongno Gu, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 o Gu, Seoul 110744, South Korea Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Hallym Univ, Coll Med, Dept Clin Pathol, Chunchon, South Korea Hallym Univ Chunchon South Korea ept Clin Pathol, Chunchon, South Korea Univ Tokyo, Fac Med, Dept Med, Tokyo, Japan Univ Tokyo Tokyo JapanUniv Tokyo, Fac Med, Dept Med, Tokyo, Japan
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 7, volume: 28, anno: 2001,
pagine: 1577 - 1583
SICI:
0315-162X(200107)28:7<1577:AOHCIG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA TOPOISOMERASE-I; SCLERODERMA-RELATED AUTOANTIBODIES; SERUM ANTINUCLEAR ANTIBODIES; HLA-DQB1 1ST DOMAIN; RACIAL-DIFFERENCES; JAPANESE PATIENTS; PCR-SSCP; T-CELL; FREQUENCIES;
Keywords:
systemic sclerosis; HLA-DR; HLA-DQ; Korean;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Park, MH Seoul Natl Univ, Coll Med, Dept Clin Pathol, Chongno Gu, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 th Korea
Citazione:
S.H. Kang et al., "Association of HLA class II genes with systemic sclerosis in Koreans", J RHEUMATOL, 28(7), 2001, pp. 1577-1583

Abstract

Objective, To investigate HLA class II associations with systemic sclerosis (SSc) in Koreans according to anti-topoisomerase I(anti-topo I), anti-centromere antibody (ACA), and anti-U1 ribonucleoprotein (RNP) status,Methods. HLA class II alleles (DRB1, DRB5, DQB1) were determined by DNA typing in 200 healthy control subjects and 74 patients with SSc: 35 anti-topoI positive, 3 ACA positive, and 19 anti-Ui RNP positive; among them were 34 diffuse and 40 limited subtypes, and 16 overlap syndrome. Results, Anti-topo I positive SSc was strongly associated with DRB1*1502 compared with both controls (23% vs 5%; P-corr = 0.003) and anti-topo I negative patients (23% vs 3%; p = 0.009); our study confirms observations in Japanese. HLA-DR (FLEDR71)-F-67, especially V-38-(FLEDR71)-F-67 sequence (carried on DRB5*0102 in linkage disequilibrium with DRB1*1502, DRB1*0802, DR81*1101), showed the strongest association with anti-topo I response (46% vs 16% in controls; p(corr) = 0.001), and L-38-(FLEDR71)-F-67 group alleles were not associated with anti-topo I response, Anti-topo I response was not significantly associated with HLA-DQB 1 alleles in Koreans. There were only 3 ACA positive patients, and all patients had DRB1*1501 and DQB1*0602 as heterozygotes. Anti-U1 RNP occurred at a high frequency (63%) among patients with overlap syndrome, and was not associated with HLA-DR or DQ genes. Among anti-topo I negative patients, diffuse and limited subtypes of SSc were significantly associated with DRB1*0803 (47% vs 15% in controls; p(corr) < 0.05) and DRB1*1501 (50% vs 17% in controls; p(corr) < 0.01), respectively. These HLA associations have not been reported in other ethnic groups and possible associations with certain autoantibody subsets remain to be confirmed. Conclusion, HLA-DR gene has a primary association with anti-topo I response, and HLA-DR V-38-(FLEDR71)-F-67 group alleles including DRB5*0102 tin linkage disequilibrium with DRB1*1502) show the strongest association with anti-topo I response in Korean patients with SSc.

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Documento generato il 23/01/21 alle ore 08:52:28