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Titolo:
Simple, rapid reagent-injection spectrophotometric determination of fluorides in pharmaceutical formulations
Autore:
Themelis, DG; Tzanavaras, PD; Tzanavaras, HD;
Indirizzi:
Aristotle Univ Thessaloniki, Analyt Chem Lab, Dept Chem, Salonika 54006, Greece Aristotle Univ Thessaloniki Salonika Greece 54006 Salonika 54006, Greece
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 5-6, volume: 25, anno: 2001,
pagine: 971 - 976
SICI:
0731-7085(200107)25:5-6<971:SRRSDO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION CHROMATOGRAPHY;
Keywords:
reagent-injection; spectrophotometry; fluoride; pharmaceuticals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Themelis, DG Aristotle Univ Thessaloniki, Analyt Chem Lab, Dept Chem, Salonika 54006, Greece Aristotle Univ Thessaloniki Salonika Greece 54006 6, Greece
Citazione:
D.G. Themelis et al., "Simple, rapid reagent-injection spectrophotometric determination of fluorides in pharmaceutical formulations", J PHARM B, 25(5-6), 2001, pp. 971-976

Abstract

A new simple and rapid reagent-injection method is reported for the determination of fluorides in pharmaceutical formulations. The method is based onthe inhibitory effect of fluoride ions upon the Fe(III) catalytic oxidation of 2,4-diaminophenol (DAP) by H2O2. Free fluoride ions form stable complexes with Fe(III), thus reducing its catalytic effect. The decrease in the absorbance of the oxidation product is monitored spectrophotometrically at 500 nm. The various chemical and physical variables of the Fl system were optimized and a study of interfering ions was also carried out. A linear calibration graph was obtained from 0 to 750 mg l(-1) for F- ions. The precision was very good (s(r) = 0.3%) and the 30 detection limit was satisfactory (c(L) = 0.471 mg l(-1)). The sampling rate was 90 injections h(-1) The method has been successfully applied to the determination of F ions in pharmaceutical Formulations. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:54:46