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Titolo:
The quantitative determination of several inhibitors of the angiotensin-converting enzyme by CE
Autore:
Hillaert, S; Van den Bossche, W;
Indirizzi:
State Univ Ghent, Fac Pharmaceut Sci, Dept Pharmaceut Anal, Lab PharmaceutChem & Drug Anal, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 & Drug Anal, B-9000 Ghent, Belgium
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 5-6, volume: 25, anno: 2001,
pagine: 775 - 783
SICI:
0731-7085(200107)25:5-6<775:TQDOSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; CAPILLARY ELECTROPHORESIS; ENALAPRIL MALEATE; ACE-INHIBITORS; SEPARATION; HYDROCHLOROTHIAZIDE; PHARMACEUTICALS; BENAZEPRIL; CILAZAPRIL; FOSINOPRIL;
Keywords:
capillary electrophoresis; ACE inhibitors; tablets; quantitative analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hillaert, S State Univ Ghent, Fac Pharmaceut Sci, Dept Pharmaceut Anal, Lab PharmaceutChem & Drug Anal, Harelbekestr 72, B-9000 Ghent, Belgium State Univ Ghent Harelbekestr 72 Ghent Belgium B-9000 Belgium
Citazione:
S. Hillaert e W. Van den Bossche, "The quantitative determination of several inhibitors of the angiotensin-converting enzyme by CE", J PHARM B, 25(5-6), 2001, pp. 775-783

Abstract

Capillary electrophoresis (CE) was applied to the study of several inhibitors of the anpiotensin-converting enzyme. Separation of the compounds was performed by means of two phosphate buffers teach 100 mM) at pH 7.0 and 6.25, respectively [S. Hillaert, W. Van den Bossche, J. Chromatogr. A, 895 (2000) 33-42.]. Due to the highest selectivity of the first mentioned running buffer, the same system has been applied for the quantification of enalapril, lisinopril, quinapril, fosinopril. perindopril and benazepril in their corresponding pharmaceutical formulation. Especially, the possibility of simultaneous identification and quantification of the active ingredient in the finished product is very attractive. Excipients do not adversely affect theresults. This paper deals with the validation of some parameters of the quantitative analysis: linearity, precision, accuracy and robustness. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:29:44