Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Identification and quantitation of sodium-thyroxine and its degradation products by LC using electrochemical and MS detection
Autore:
Kazemifard, AG; Moore, DE; Aghazadeh, A;
Indirizzi:
Med Sci Univ Tehran, Coll Pharm, Tehran, Iran Med Sci Univ Tehran TehranIran i Univ Tehran, Coll Pharm, Tehran, Iran Univ Sydney, Dept Pharm, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 Pharm, Sydney, NSW 2006, Australia
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 5-6, volume: 25, anno: 2001,
pagine: 697 - 711
SICI:
0731-7085(200107)25:5-6<697:IAQOSA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; CONTENT UNIFORMITY; TABLET FORMULATIONS; MASS-SPECTROMETRY; LEVOTHYROXINE; LIOTHYRONINE; METABOLITES; DISSOLUTION; ASSAY; HPLC;
Keywords:
sodium-thyroxine; degradation products; high-performance liquid chromatography; amperometric detection; HPLC-mass spectrometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kazemifard, AG Med Sci Univ Tehran, Coll Pharm, Tehran, Iran Med Sci Univ Tehran Tehran Iran Coll Pharm, Tehran, Iran
Citazione:
A.G. Kazemifard et al., "Identification and quantitation of sodium-thyroxine and its degradation products by LC using electrochemical and MS detection", J PHARM B, 25(5-6), 2001, pp. 697-711

Abstract

High performance liquid chromatography (HPLC) was used in combination withan amperometric and mass spectrometric detection to elucidate and quantitate the degradation products and contaminants of the photo-sensitive Na-thyroxine. Using HPLC with amperometric detection, seven decomposition compounds were separated. These products, which occur mostly as contaminants, were then identified by a developed liquid chromatography-mass spectrometry technique. The same HPLC method was also employed to analyze Na-thyroxine and its degradation products in three commercially available brands of Na-thyroxine tablets. (C) 2001 Elsevier Science B.V. AH rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:30:55