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Titolo:
Effect of sucrose addition to drinking water, that induces hypertension inthe rats, on liver microsomal Delta 9 and Delta 5-desaturase activities
Autore:
El Hafidi, M; Cuellar, A; Ramirez, J; Banos, G;
Indirizzi:
Inst Nacl Cardiol Ignacio Chavez, Dept Bioquim, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico 14080 , DF, Mexico UNAM, Inst Fisiol Celular, Dept Microbiol, Mexico City 14080, DF, Mexico UNAM Mexico City DF Mexico 14080 Microbiol, Mexico City 14080, DF, Mexico
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 396 - 403
SICI:
0955-2863(200107)12:7<396:EOSATD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID METABOLISM; STEAROYL-COA DESATURASE; BLOOD-PRESSURE; HYPERTRIGLYCERIDEMIA; CHOLESTEROL; PATHOGENESIS; LYMPHOCYTES; HEPATOCYTES; INSULIN; OBESITY;
Keywords:
sucrose intake; desaturase activities; hypertriglyceridemia; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: El Hafidi, M Inst Nacl Cardiol Ignacio Chavez, Dept Bioquim, Juan Badiano 1, Mexico City 14080, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Juan Badiano 1 Mexico City DF Mexico 14080
Citazione:
M. El Hafidi et al., "Effect of sucrose addition to drinking water, that induces hypertension inthe rats, on liver microsomal Delta 9 and Delta 5-desaturase activities", J NUTR BIOC, 12(7), 2001, pp. 396-403

Abstract

This study was undertaken with the aim of investigating the effect of sucrose addition to the drinking water of rats who were fed with the same diet as a control group, on Delta9- and Delta5-desaturase activities and on the fatty acid composition of serum and liver microsomes. Weanling male Wistar rats had 30% sucrose in their drinking water for 20 weeks. An increase in total calories consumed, visceral fat accumulation, insulin, triglycerides and blood pressure and a decrease in the food Intake were observed in the sucrose-fed group as compared with the control group. A decrease in. Linoleicand alpha -linolenic acid (essential fatty acids) in all serum lipid fractions of sucrose-fed rats was found. This observation correlated with a low food intake by sucrose-fed rats. The conversion of [1 C-14]-palmitic to [1 C-14]-palmitoleic acid by Delta9-desaturase activity was increased in sucrose-fed compared with control rats, while the conversion of [1 C-14]-dihomo-gamma -linolenic acids by Delta5-desaturase activity was depressed. In sucrose-fed as compared to control rats, the proportion of palmitoleic and oleic fatty acids was increased. Arachidonic acid was decreased in sucrose-fed rats. The 1,6-diphenylhexatriene fluorescence polarization of the microsomal membranes was significantly lower in the sucrose-fed group compared to the control group. These results indicate that the sucrose addition to the drinking water of the rats increased microsomal Delta9-desaturase activity and membrane disorder and decreased the activity of the Delta5-desaturase, a key enzyme in the biosynthesis of arachidonic acid, implicated in hypertension. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 27/01/20 alle ore 07:25:24