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Titolo:
Altered respiratory activity and respiratory regulations in adult monoamine oxidase A-deficient mice
Autore:
Burnet, H; Bevengut, M; Chakri, F; Bou-Flores, C; Coulon, P; Gaytan, S; Pasaro, R; Hilaire, G;
Indirizzi:
Ctr Natl Rech Sci Dev & Pathol Mouvement Biol Ryt, F-13402 Marseille 20, France Ctr Natl Rech Sci Dev & Pathol Mouvement Biol Ryt Marseille France 20 ce Ctr Natl Rech Sci, F-13009 Marseille, France Ctr Natl Rech Sci MarseilleFrance F-13009 ci, F-13009 Marseille, France Univ Sevilla, Fac Biol, Dept Fisiol & Biol Anim, E-41012 Seville, Spain Univ Sevilla Seville Spain E-41012 l & Biol Anim, E-41012 Seville, Spain
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 21, anno: 2001,
pagine: 5212 - 5221
SICI:
0270-6474(20010715)21:14<5212:ARAARR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; PHRENIC MOTONEURON ACTIVITY; BREUER-HERING REFLEX; SUBSTANCE-P; RABIES VIRUS; IN-VITRO; TRANSNEURONAL TRACER; SEROTONIN EXCESS; SPINAL-CORD; RAT;
Keywords:
breathing patterns; inspiratory neuron and motoneuron firing activity; respiratory regulations; morphology of motoneurons; serotonin; maturation; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bevengut, M Ctr Natl Rech Sci Dev & Pathol Mouvement Biol Ryt, BP 71, F-13402 Marseille 20, France Ctr Natl Rech Sci Dev & Pathol Mouvement Biol Ryt BP 71 Marseille France 20
Citazione:
H. Burnet et al., "Altered respiratory activity and respiratory regulations in adult monoamine oxidase A-deficient mice", J NEUROSC, 21(14), 2001, pp. 5212-5221

Abstract

The abnormal metabolism of serotonin during the perinatal period alters respiratory network maturation at birth as revealed by comparing the monoamine oxidase A-deficient transgenic (Tg8) with the control (C3H) mice (Bou-Flores et al., 2000). To know whether these alterations occur only transientlyor induce persistent respiratory dysfunction during adulthood, we studied the respiratory activity and regulations in adult C3H and Tg8 mice. First, plethysmographic and pneumotachographic analyses of breathing patterns revealed weaker tidal volumes and shorter inspiratory durations in Tg8 than in C3H mice. Second, electrophysiological studies showed that the firing activity of inspiratory medullary neurons and phrenic motoneurons is higher in Tg8 mice and that of the intercostal motoneurons in C3H mice. Third, histological studies indicated abnormally large cell bodies of Tg8 intercostal butnot phrenic motoneurons. Finally, respiratory responses to hypoxia and lung inflation are weaker in Tg8 than in C3H mice. DL-p-chlorophenyl-alanine treatments applied to Tg8 mice depress the high serotonin level present during adulthood; the treated mice recover normal respiratory responses to bothhypoxia and lung inflation, but their breathing parameters are not significantly affected. Therefore in Tg8 mice the high serotonin level occurring during the perinatal period alters respiratory network maturation and produces a permanent respiratory dysfunction, whereas the high serotonin level present in adults alters the respiratory regulatory processes. In conclusion,the metabolism of serotonin plays a crucial role in the maturation of the respiratory network and in both the respiratory activity and the respiratory regulations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:27:42