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Titolo:
Genetic control of the mouse cerebellum: Identification of quantitative trait loci modulating size and architecture
Autore:
Airey, DC; Lu, L; Williams, RW;
Indirizzi:
Univ Tennessee, Ctr Neurosci, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 , Ctr Neurosci, Memphis, TN 38163 USA Univ Tennessee, Dept Anat & Neurobiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 at & Neurobiol, Memphis, TN 38163 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 21, anno: 2001,
pagine: 5099 - 5109
SICI:
0270-6474(20010715)21:14<5099:GCOTMC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLIAL PATTERN; COMPLEX TRAITS; INBRED MICE; BRAIN; CELL; MAP; PRECEREBELLIN; EXPRESSION; EVOLUTION; CROSSES;
Keywords:
neurogenetics; quantitative trait locus; QTL; cerebellum; internal granule cell layer; IGL; C57BL/6J; DBA/2J; BXD; recombinant inbred strain; F2 intercross; folia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Airey, DC Univ Tennessee, Ctr Neurosci, 855 Monroe Ave, Memphis, TN 38163 USA Univ Tennessee 855 Monroe Ave Memphis TN USA 38163 TN 38163 USA
Citazione:
D.C. Airey et al., "Genetic control of the mouse cerebellum: Identification of quantitative trait loci modulating size and architecture", J NEUROSC, 21(14), 2001, pp. 5099-5109

Abstract

To discover genes influencing cerebellum development, we conducted a complex trait analysis of variation in the size of the adult mouse cerebellum. We analyzed two sets of recombinant inbred BXD strains and an F2 intercross of the common inbred strains, C57BL/6J and DBA/2J. We measured cerebellar size as the weight or volume of fixed or histologically processed tissue. Among BXD recombinant inbred strains, the cerebellum averages 52 mg (12.4% ofthe brain) and ranges 18 mg in size. In F2 mice, the cerebellum averages 62 mg (12.9% of the brain) and ranges similar to 20 mg in size. Five quantitative trait loci (QTLs) that significantly control Variation in cerebellar size were mapped to chromosomes 1 (Cbs1a), 8 (Cbs8a), 14 (Cbs14a), and 19 (Cbs19a, Cbs19b). In combination, these QTLs can shift cerebellar size an appreciable 35% of the observed range. To assess regional genetic control of the cerebellum, we also measured the volume of the cell-rich, internal granule layer (IGL) in a set of BXD strains. The IGL ranges from 34 to 43% of total cerebellar volume. The QTL Cbs8a is significantly linked to variation in IGL volume and is suggestively linked to variation in the number of cerebellar folia. The QTLs we have discovered are among the first loci shown tomodulate the size and architecture of the adult mouse cerebellum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 16:46:34