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Titolo:
Death in the balance: Alternative participation of the caspase-2 and-9 pathways in neuronal death induced by nerve growth factor deprivation
Autore:
Troy, CM; Rabacchi, SA; Hohl, JB; Angelastro, JM; Greene, LA; Shelanski, ML;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Pathol, Taub Inst Study Alzheimers Dis & Aging Brain, New York, NY 10032 USA Columbia Univ Coll Phys & Surg NewYork NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 21, anno: 2001,
pagine: 5007 - 5016
SICI:
0270-6474(20010715)21:14<5007:DITBAP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPRIVED PC12 CELLS; X-LINKED IAP; CYTOCHROME-C; SYMPATHETIC NEURONS; DOWN-REGULATION; IN-VIVO; APOPTOSIS; PROTEIN; ACTIVATION; MICE;
Keywords:
trophic factor deprivation; neuronal cell death; caspases; caspase-2; caspase-9; IAPs; DIABLO/Smac; sympathetic neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Troy, CM Columbia Univ Coll Phys & Surg, Dept Pathol, Taub Inst Study Alzheimers Dis & Aging Brain, 630 W 168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St New York NY USA 10032
Citazione:
C.M. Troy et al., "Death in the balance: Alternative participation of the caspase-2 and-9 pathways in neuronal death induced by nerve growth factor deprivation", J NEUROSC, 21(14), 2001, pp. 5007-5016

Abstract

The data presented here demonstrate that sympathetic neurons have the potential to activate two alternative caspase-dependent pathways either of which is capable of mediating death induced by NGF deprivation and that these neurons have the potential to switch from one pathway to the other. The presence of these two alternative pathways to trophic factor deprivation-induced death may have implications for ensuring the correct development of the nervous system. In wild-type neurons, a caspase-2-dependent pathway is required for death, and a caspase-9-dependent pathway appears to be suppressed by endogenous inhibitors of apoptosis proteins (IAPs). In contrast, for caspase-2-null neurons, death is dependent on the caspase-9 pathway. The mechanism underlying the shift is the result of a threefold compensatory elevation of caspase-9 expression and a doubling of levels of direct TAP binding protein with low pl/second mitochondria-derived activator of caspase, an IAP inhibitor, both at the mRNA and protein levels. These findings resolve seemingly discrepant findings regarding the roles of various caspases after NGFdeprivation and raise a cautionary note regarding the interpretation of findings with caspase-null animals. The choice of the death-mediating caspasepathway in the sympathetic neurons is thus dependent on the regulated relative expression of components of the pathways including those of caspases, IAPs, and IAP inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:07:47