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Titolo:
The Ras signaling pathway in mammary tumorigenesis and metastasis
Autore:
Malaney, S; Daly, RJ;
Indirizzi:
Garvan Inst Med Res, Canc Res Program, Sydney, NSW, Australia Garvan Inst Med Res Sydney NSW Australia Program, Sydney, NSW, Australia
Titolo Testata:
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
fascicolo: 1, volume: 6, anno: 2001,
pagine: 101 - 113
SICI:
1083-3021(200101)6:1<101:TRSPIM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BREAST-CANCER; ACTIVATED PROTEIN-KINASE; EPIDERMAL-GROWTH-FACTOR; CELL-CYCLE PROGRESSION; GRB2 ADAPTER PROTEIN; C-HA-RAS; TRANSGENIC MICE; EPITHELIAL-CELLS; INSULIN-RECEPTOR; ONCOGENE EXPRESSION;
Keywords:
breast cancer; Ras; MAP kinase; Erks tumorigenesis; metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Daly, RJ Garvan Inst Med Res, Canc Res Program, Sydney, NSW, Australia Garvan Inst Med Res Sydney NSW Australia Sydney, NSW, Australia
Citazione:
S. Malaney e R.J. Daly, "The Ras signaling pathway in mammary tumorigenesis and metastasis", J MAMMARY G, 6(1), 2001, pp. 101-113

Abstract

The Ras superfamily of GTPases act as important regulatory switches to co-ordinate extracellular stimuli with activation of intracellular signaling pathways and appropriate biological responses. The Ras branch of this superfamily includes H-, K- and N-Ras, which are commonly mutated in particular human cancers, but notably not in those of the breast. Instead, in breast cancer the signaling pathways involving these GTPases may be upregulated due to increased coupling to growth factor receptors or other tyrosine kinases commonly overexpressed in this disease, or increased expression of regulators, the Ras protein itself, or downstream effecters. Functional studies utilizing both in vitro and in vivo models demonstrate that Ras signaling can regulate a variety of endpoints relevant to breast cancer progression, including anchorage dependent and independent growth, tumorigenesis, steroid sensitivity and invasion. Finally, analysis of the processing and signaling mechanisms of the Ras superfamily has identified potential targets for therapeutic intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 15:40:57