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Titolo:
Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis
Autore:
Scheid, MP; Woodgett, JR;
Indirizzi:
Ontario Canc Inst, Toronto, ON M5G 2M9, Canada Ontario Canc Inst Toronto ON Canada M5G 2M9 , Toronto, ON M5G 2M9, Canada
Titolo Testata:
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
fascicolo: 1, volume: 6, anno: 2001,
pagine: 83 - 99
SICI:
1083-3021(200101)6:1<83:P3KSIM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; GLYCOGEN-SYNTHASE KINASE-3; PLECKSTRIN HOMOLOGY DOMAIN; INTEGRIN-LINKED KINASE; INSULIN-RECEPTOR SUBSTRATE-1; PHOSPHOINOSITIDE 3-OH KINASE; BANNAYAN-ZONANA-SYNDROME; PROMOTES CELL-SURVIVAL; TUMOR-SUPPRESSOR GENE; MIDDLE T-ANTIGEN;
Keywords:
PKB/Akt; PI3K; PDK-1; apoptosis; tumorigenesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
156
Recensione:
Indirizzi per estratti:
Indirizzo: Woodgett, JR Ontario Canc Inst, 610 Univ Ave, Toronto, ON M5G 2M9, Canada Ontario Canc Inst 610 Univ Ave Toronto ON Canada M5G 2M9 nada
Citazione:
M.P. Scheid e J.R. Woodgett, "Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis", J MAMMARY G, 6(1), 2001, pp. 83-99

Abstract

Suppression of apoptosis is now recognized as a key contributory element to tumorigenesis in animal models and human cancer. The phosphatidylinositol3 ' kinase pathway plays a seminal role in cell death suppression or "survival signaling. " Over the past 5 years, the molecular mechanisms by which this pathway exerts its death suppressive effects have slowly been revealed. This review summarizes the players involved, their importance in human cancer and their specific involvement in breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:44:54