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Titolo:
Chemokine receptors in human basophils: inducible expression of functionalCXCR4
Autore:
Iikura, M; Miyamasu, M; Yamaguchi, M; Kawaskai, H; Matsushima, K; Kitaura, M; Morita, Y; Yoshie, O; Yamamoto, K; Hirai, K;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Bioregulatory Funct, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 ry Funct, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Allergy & Rheumatol, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Mol Prevent Med, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 ept Mol Prevent Med, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, CREST, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Grad Sch Med, CREST, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Resp Med, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Med, Dept Resp Med, Tokyo 1138655, Japan Univ Tokyo, Inst Med Sci, Dept Clin Immunol, Tokyo, Japan Univ Tokyo Tokyo Japan o, Inst Med Sci, Dept Clin Immunol, Tokyo, Japan Univ Tokyo, Inst Med Sci, Ctr AIDS Res, Tokyo, Japan Univ Tokyo Tokyo Japan Tokyo, Inst Med Sci, Ctr AIDS Res, Tokyo, Japan Shionogi Inst Med Sci, Osaka, Japan Shionogi Inst Med Sci Osaka JapanShionogi Inst Med Sci, Osaka, Japan Kinki Univ, Dept Bacteriol, Osaka, Japan Kinki Univ Osaka JapanKinki Univ, Dept Bacteriol, Osaka, Japan
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 1, volume: 70, anno: 2001,
pagine: 113 - 120
SICI:
0741-5400(200107)70:1<113:CRIHBI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTAMINE-RELEASING FACTOR; CHEMOTACTIC AGONISTS; BLOOD BASOPHILS; GROWTH-FACTORS; CELLS; EOSINOPHILS; ACTIVATION; IL-4; DEGRANULATION; EOTAXIN;
Keywords:
SDF-1; CCR5; migration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hirai, K Univ Tokyo, Grad Sch Med, Dept Bioregulatory Funct, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 Tokyo 1138655, Japan
Citazione:
M. Iikura et al., "Chemokine receptors in human basophils: inducible expression of functionalCXCR4", J LEUK BIOL, 70(1), 2001, pp. 113-120

Abstract

We examined the expression profile of chemokine receptors in human basophils and their regulation by cytokines, Basophils expressed transcripts of CCchemokine receptors (CCR)1, CCR2, CCRS, and CCR5 and CXC chemokine receptors (CXCR)1, CXCR2, and CXCR4.. In contrast to the other receptors, surface-CXCR4 expression was not detected in fresh- and whole-blood basophils, but it became apparent gradually during incubation, Among 16 chemokines tested,eotaxin induced the most potent basophil migration. SDF-1 also induced a strong, migratory response comparable with that induced by eotaxin in 24-h, cultured basophils, but it failed to induce degranulation, IL-3 abrogated CXCR4 expression completely, and it only down-regulated CCR2 and CCR3 expression slightly, IL-5, GM-CSF, and IL-4 also down-regulated CXCR4 expression,Thus, expression of CXCR4 was the most strongly affected by cytokines, andthis may represent an alternative mechanism for control of cell-specific, biological responses to SDF-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:26:46