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Titolo:
Graft-versus-host reaction in small-bowel transplantation and possibilities for its circumvention
Autore:
Watanabe, K; Yagi, T; Iwagaki, H; Kimura, Y; Mitsuoka, N; Inagaki, M; Tanaka, S; Tanaka, N;
Indirizzi:
Okayama Univ, Sch Med, Dept Surg 1, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Surg 1, Okayama 7008558, Japan
Titolo Testata:
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
fascicolo: 3, volume: 29, anno: 2001,
pagine: 222 - 228
SICI:
0300-0605(200105/06)29:3<222:GRISTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENTERIC LYMPH-NODES; LIVER-TRANSPLANTATION; DISEASE; DONOR;
Keywords:
small-bowel transplantation; graft-versus-host reaction; immunological challenge;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Iwagaki, H Okayama Univ, Sch Med, Dept Surg 1, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 58, Japan
Citazione:
K. Watanabe et al., "Graft-versus-host reaction in small-bowel transplantation and possibilities for its circumvention", J INT MED R, 29(3), 2001, pp. 222-228

Abstract

To study graft-versus-host reaction (GVHR) in small-bowel transplantation and its underlying mechanisms and to find methods for circumventing GVHR, we used an unidirectional GVHR model in which F-1 Lewis (LEW) x Wistar King A (WKA) hybrid rats received small-bowel transplants from either LEW or WKAparent rats. The survival time of F-1 hybrid rats that received full-length small-bowel transplantation from LEW and WKA was 16.3 +/- 2.1 days and 18.2 +/- 3.4 days, respectively. When one-quarter of LEW small bowel was transplanted to an F-1 hybrid recipient, the survival time was significantly longer at 44.0 +/- 23.4 days compared with rats that had received full-lengthLEW small-bowel transplantation. The survival time of F-1 hybrid rats which received an injection of high-dose (5 x 10(8) cells) LEW or WKA spleen cells was 11.9 +/- 4.0 days and 13.1 +/- 3.6 days, respectively. However, when an injection containing a low dose (1 x 10(8) cells) of LEW spleen cells was used, survival was > 100 days, showing significance compared with the survival of rats receiving the higher dose LEW spleen-cell injection. Both small-bowel transplantation and spleen-cell injection were compared for the effective period of recipient resistance to donor cell or small-bowel transplantation as second challenge. When the F-1 rats given a quarter LEW small-bowel transplant as first challenge were treated with a high-dose of spleen cells 30 days after transplantation, they survived for > 30 days without GVHR. F-1 rats that were treated with a low-dose LEW spleen-cell injection,followed 30 days later by full LEW small-bowel transplantation, had a survival time of > 100 days. These results indicate that segmental small-bowel transplantation and spleen-cell injection as first challenge may facilitatethe prevention of GVHR, resulting in resistance to subsequent immunological challenge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:36:52