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Titolo: Immunomodulation based on a two-way paradigm with deoxyspergualin alleviates graft-versus-host reaction in small-bowel transplantation in rats
Autore: Kimura, Y; Yagi, T; Iwagaki, H; Watanabe, K; Kai, K; Yamamura, M; Inagaki, M; Tanaka, S; Tanaka, N;
- Indirizzi:
- Okayama Univ, Dept Surg 1, Sch Med, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 rg 1, Sch Med, Okayama 7008558, Japan
- Titolo Testata:
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
fascicolo: 3,
volume: 29,
anno: 2001,
pagine: 214 - 221
- SICI:
- 0300-0605(200105/06)29:3<214:IBOATP>2.0.ZU;2-P
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- BONE-MARROW TRANSPLANTATION; LIVER-TRANSPLANTATION; DISEASE; PREVENTION; BLOOD; CELLS; DONOR;
- Keywords:
- deoxyspergualin; small-bowel transplantation; graft-versus-host reaction; bone-marrow cell;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Clinical Medicine
- Life Sciences
- Citazioni:
- 20
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Iwagaki, H Okayama Univ, Dept Surg 1, Sch Med, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 58, Japan
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- Citazione:
- Y. Kimura et al., "Immunomodulation based on a two-way paradigm with deoxyspergualin alleviates graft-versus-host reaction in small-bowel transplantation in rats", J INT MED R, 29(3), 2001, pp. 214-221
Abstract
In this study, we investigated whether or not deoxyspergualin used as donor pretreatment, with and without pretreatment using bone-marrow-cell injection, could alleviate graft-versus-host reaction (GVHR) following small-bowel transplantation in an unidirectional GVHR model with Lewis (LEM)-to-F-1 rats. In addition, we studied the effect of deoxyspergualin plus bone-marrow-cell donor pre-operative treatment in combination with recipient post-operative treatment using deoxyspergualin. When the donor was pretreated with bone-marrow cells from recipient rats, the recipient died at 7.2 +/- 1.4 days, showing significantly shorter survival compared with the control group. Deoxyspergualin, when employed either alone as recipient post-treatment or as donor pretreatment, both with and without additional pretreatment with F-1 recipient bone-marrow-cell injection, did not result. in significant prolongation of recipient survival. The combination of donor pretreatment withdeoxyspergualin plus F-1 bone-marrow-cell injection followed by post-operative deoxyspergualin administration, however, resulted in significant prolongation in recipient survival compared with control (26.1 +/- 1.7 days). Inaddition, no severe cutaneous lesions on GVHR were seen throughout the observation period. This suggests that donor pretreatment deoxyspergualin and recipient bone-marrow-cell injection combined with postoperative deoxyspergualin administration can lead to resistance to GVHR after parent-to-F-1 small-bowel transplantation.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:38:56