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Titolo:
Schedule-dependent combined sensitivity testing of anti-cancer agents in human gastric carcinoma cell lines
Autore:
Murashima, N; Gochi, A; Kenmotsu, M; Hamazaki, K; Funaki, M; Ohtsuka, S; Tanaka, N;
Indirizzi:
Okayama Univ, Sch Med, Dept Surg 1, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Surg 1, Okayama 7008558, Japan
Titolo Testata:
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
fascicolo: 3, volume: 29, anno: 2001,
pagine: 189 - 197
SICI:
0300-0605(200105/06)29:3<189:SCSTOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE METHOTREXATE; COMBINATION CHEMOTHERAPY; EUROPEAN-ORGANIZATION; COOPERATIVE GROUP; PHASE-II; 5-FLUOROURACIL; CISPLATIN; DOXORUBICIN; TRIAL; MITOMYCIN;
Keywords:
cisplatin; doxorubicin; etoposide; combination chemotherapy; anti-cancer agents; gastric carcinoma; sensitivity testing; cytotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gochi, A Okayama Univ, Sch Med, Dept Surg 1, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8558, Japan
Citazione:
N. Murashima et al., "Schedule-dependent combined sensitivity testing of anti-cancer agents in human gastric carcinoma cell lines", J INT MED R, 29(3), 2001, pp. 189-197

Abstract

The efficacy of combination chemotherapy for gastric carcinoma has been unsatisfactory, although the prognosis of advanced and recurrent disease has improved with the introduction of cisplatin (CDDP). This study examines theeffect of the anti-cancer therapies CDDP, doxorubicin (ADM) and etoposide (VP-16) on the cell cycle and their cytotoxicity against two gastric carcinoma cell lines: MKN-28 (well differentiated) and MKN-45 (poorly differentiated). The treatments have different cytocidal mechanisms, and they were studied in dual combinations. For all combinations studied, cytotoxicity against MKN-45 was higher than against MKN-28. for ADM plus CDDP, or ADM plus VP-16, cytotoxicity was higher in patients pretreated with ADM than other regimens. The highest anti-tumour activity against both cell lines was obtained with ADM followed by CDDP (we have obtained good clinical results with this regimen). Schedule-dependent combined sensitivity testing of anti-canceragents will be useful for the clinical application of therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:32:51